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Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus

Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 A, 00250 Helsinki, Finland
Department of Medical Microbiology and Immunology, Aarhus University, The Bartholin Building, 8000 Aarhus C, Denmark
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 737-759;
Received: 17 August 2009 / Revised: 3 November 2009 / Accepted: 5 November 2009 / Published: 5 November 2009
(This article belongs to the Special Issue Interferon Antiviral Response and Viral Evasion)
Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV. View Full-Text
Keywords: herpes simplex virus; evasion; innate; interferon; viral immunity herpes simplex virus; evasion; innate; interferon; viral immunity
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Melchjorsen, J.; Matikainen, S.; Paludan, S.R. Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus. Viruses 2009, 1, 737-759.

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