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Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections

by Thomas Baranek 1,2,3,†, Nicolas Zucchini 1,2,3,† and Marc Dalod 1,2,3,*
1
Université de la Méditerranée, Centre d’Immunologie de Marseille-Luminy, Parc Scientifique & Technologique de Luminy, Case 906, F13288 Marseille, Cedex 09, France
2
Institut National de la Santé et de la Recherche Médicale (INSERM), U631, Centre d’Immunologie de Marseille-Luminy, Parc Scientifique & Technologique de Luminy, Case 906, F13288 Marseille, Cedex 09, France
3
Centre National de la Recherche Scientifique (CNRS), UMR6102, Centre d’Immunologie de Marseille-Luminy, Parc Scientifique & Technologique de Luminy, Case 906, F13288 Marseille, Cedex 09, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2009, 1(3), 383-419; https://doi.org/10.3390/v1030383
Received: 10 August 2009 / Revised: 1 October 2009 / Accepted: 8 October 2009 / Published: 14 October 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
Type-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease. View Full-Text
Keywords: plasmacytoid dendritic cell; type-I interferon; mouse cytomegalovirus; human cytomegalovirus; herpesvirus type 1; herpesvirus type 2; immunotherapy plasmacytoid dendritic cell; type-I interferon; mouse cytomegalovirus; human cytomegalovirus; herpesvirus type 1; herpesvirus type 2; immunotherapy
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Baranek, T.; Zucchini, N.; Dalod, M. Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections. Viruses 2009, 1, 383-419.

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