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Open AccessArticle

Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel

1
Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan
2
Institute of Oral Medicine, National Cheng Kung University, Tainan 70101, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: James Z. Tang and Charley Chuan-yu Wu
Materials 2016, 9(9), 761; https://doi.org/10.3390/ma9090761
Received: 14 July 2016 / Revised: 26 August 2016 / Accepted: 2 September 2016 / Published: 7 September 2016
(This article belongs to the Special Issue Materials for Drug Delivery and Biomedical Consideration)
The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37 °C. Briefly, the suitable oil phase with paclitaxel significantly dissolved is microemulsified with appropriate surfactants. Surfactants utilized include Tween 80, Cremophor EL, and polyethylene glycol (4.3) cocoyl ether, while various kinds of edible oils and fatty esters are used as the oil phase. On average, the apparent solubility of paclitaxel is increased to ca. 70–100 ppm in the prepared microemulsions at 37 °C using tributyrin or ethyl caproate as the oil phases. The sizes of the microemulsions attained are mostly from ca. 60 nm to ca. 200 nm. The cytotoxicity of the microemulsion formulations is assessed with the cellular viability of 3T3 cells. In general, the cell viability is above 55% after 24 h of cultivation in media containing these microemulsion formulations diluted to a concentration of total surfactants equal to 50 ppm and 200 ppm. View Full-Text
Keywords: paclitaxel; microemulsion; solubilizer; nonionic-surfactant; oil phase; co-surfactant paclitaxel; microemulsion; solubilizer; nonionic-surfactant; oil phase; co-surfactant
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MDPI and ACS Style

Lo, J.-T.; Lee, T.-M.; Chen, B.-H. Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel. Materials 2016, 9, 761.

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