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Materials 2016, 9(8), 646;

Microfabrication for Drug Delivery

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 1H9, Canada
Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul 130-701, Korea
Department of Materials Science and Chemical Engineering, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Subbu S. Venkatraman
Received: 24 June 2016 / Revised: 14 July 2016 / Accepted: 26 July 2016 / Published: 1 August 2016
(This article belongs to the Section Biomaterials)
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This review is devoted to discussing the application of microfabrication technologies to target challenges encountered in life processes by the development of drug delivery systems. Recently, microfabrication has been largely applied to solve health and pharmaceutical science issues. In particular, fabrication methods along with compatible materials have been successfully designed to produce multifunctional, highly effective drug delivery systems. Microfabrication offers unique tools that can tackle problems in this field, such as ease of mass production with high quality control and low cost, complexity of architecture design and a broad range of materials. Presented is an overview of silicon- and polymer-based fabrication methods that are key in the production of microfabricated drug delivery systems. Moreover, the efforts focused on studying the biocompatibility of materials used in microfabrication are analyzed. Finally, this review discusses representative ways microfabrication has been employed to develop systems delivering drugs through the transdermal and oral route, and to improve drug eluting implants. Additionally, microfabricated vaccine delivery systems are presented due to the great impact they can have in obtaining a cold chain-free vaccine, with long-term stability. Microfabrication will continue to offer new, alternative solutions for the development of smart, advanced drug delivery systems. View Full-Text
Keywords: microfabrication; drug delivery; biocompatibility microfabrication; drug delivery; biocompatibility

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Koch, B.; Rubino, I.; Quan, F.-S.; Yoo, B.; Choi, H.-J. Microfabrication for Drug Delivery. Materials 2016, 9, 646.

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