Next Article in Journal
Enrichment of Cellulosic Waste Hemp (Cannabis sativa) Hurd into Non-Toxic Microfibres
Previous Article in Journal
Bonding of TRIP-Steel/Al2O3-(3Y)-TZP Composites and (3Y)-TZP Ceramic by a Spark Plasma Sintering (SPS) Apparatus
Previous Article in Special Issue
Recyclability of PET/WPI/PE Multilayer Films by Removal of Whey Protein Isolate-Based Coatings with Enzymatic Detergents
Open AccessFeature PaperCommunication

Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

1
Lehrstuhl Biomaterialien, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95447, Germany
2
DWI Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen 52056, Germany
3
Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, Potsdam 14476, Germany
4
Physical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz D-78457, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Marek M. Kowalczuk
Materials 2016, 9(7), 560; https://doi.org/10.3390/ma9070560
Received: 1 March 2016 / Revised: 6 June 2016 / Accepted: 24 June 2016 / Published: 11 July 2016
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering. View Full-Text
Keywords: spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering
Show Figures

Figure 1

MDPI and ACS Style

Hardy, J.G.; Torres-Rendon, J.G.; Leal-Egaña, A.; Walther, A.; Schlaad, H.; Cölfen, H.; Scheibel, T.R. Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering. Materials 2016, 9, 560.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop