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Open AccessFeature PaperArticle

Polystyrene-co-Divinylbenzene PolyHIPE Monoliths in 1.0 mm Column Formats for Liquid Chromatography

1
National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
2
Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Department of Science, Waterford Institute of Technology, Waterford, Ireland
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Dermot Brabazon
Materials 2016, 9(3), 212; https://doi.org/10.3390/ma9030212
Received: 18 January 2016 / Revised: 26 February 2016 / Accepted: 15 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Porous Monolithic Materials for Applications in Separation Science)
The reversed phase liquid chromatographic (RP-HPLC) separation of small molecules using a polystyrene-co-divinylbenzene (PS-co-DVB) polyHIPE stationary phases housed within 1.0 mm i.d. silcosteel columns is presented within this study. A 90% PS-co-DVB polyHIPE was covalently attached to the walls of the column housing by prior wall modification with 3-(trimethoxysilyl) propyl methacrylate and could withstand operating backpressures in excess of 200 bar at a flow rate of 1.2 mL/min. Permeability studies revealed that the monolith swelled slightly in 100% acetonitrile relative to 100% water but could nevertheless be used to separate five alkylbenzenes using a flow rate of 40 µL/min (linear velocity: 0.57 mm/s). Remarkable column-to-column reproducibility is shown with retention factor variation between 2.6% and 6.1% for two separately prepared columns. View Full-Text
Keywords: polystyrene; polyHIPE; silcosteel; microbore; reversed phase LC; isocratic separation polystyrene; polyHIPE; silcosteel; microbore; reversed phase LC; isocratic separation
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MDPI and ACS Style

Choudhury, S.; Fitzhenry, L.; White, B.; Connolly, D. Polystyrene-co-Divinylbenzene PolyHIPE Monoliths in 1.0 mm Column Formats for Liquid Chromatography. Materials 2016, 9, 212.

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