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Materials 2016, 9(3), 198;

Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers

Department of Materials Engineering, Tatung University, Taipei 10461, Taiwan
Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Aldo Boccaccini
Received: 29 January 2016 / Revised: 2 March 2016 / Accepted: 10 March 2016 / Published: 15 March 2016
(This article belongs to the Section Biomaterials)
Full-Text   |   PDF [3078 KB, uploaded 15 March 2016]   |  


Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering. View Full-Text
Keywords: nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold

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Wu, H.-C.; Wang, T.-W.; Sun, J.-S.; Lee, Y.-H.; Shen, M.-H.; Tsai, Z.-R.; Chen, C.-Y.; Hsu, H.-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials 2016, 9, 198.

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