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Open AccessArticle

Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers

1
Department of Materials Engineering, Tatung University, Taipei 10461, Taiwan
2
Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
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Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan
4
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
5
Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Aldo Boccaccini
Materials 2016, 9(3), 198; https://doi.org/10.3390/ma9030198
Received: 29 January 2016 / Revised: 2 March 2016 / Accepted: 10 March 2016 / Published: 15 March 2016
(This article belongs to the Section Biomaterials)
Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering. View Full-Text
Keywords: nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold
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MDPI and ACS Style

Wu, H.-C.; Wang, T.-W.; Sun, J.-S.; Lee, Y.-H.; Shen, M.-H.; Tsai, Z.-R.; Chen, C.-Y.; Hsu, H.-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials 2016, 9, 198.

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