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Materials 2015, 8(11), 7498-7510;

Enhanced Stability of Calcium Sulfate Scaffolds with 45S5 Bioglass for Bone Repair

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
College of Chemistry, Xiangtan University, Xiangtan 411105, China
Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha 410011, China
School of Basic Medical Science, Central South University, Changsha 410078, China
Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China
Author to whom correspondence should be addressed.
Academic Editor: Aldo R. Boccaccini
Received: 1 September 2015 / Revised: 29 October 2015 / Accepted: 2 November 2015 / Published: 6 November 2015
(This article belongs to the Section Biomaterials)
Full-Text   |   PDF [6299 KB, uploaded 6 November 2015]   |  


Calcium sulfate (CaSO4), as a promising tissue repair material, has been applied widely due to its outstanding bioabsorbability and osteoconduction. However, fast disintegration, insufficient mechanical strength and poor bioactivity have limited its further application. In the study, CaSO4 scaffolds fabricated by using selective laser sintering were improved by adding 45S5 bioglass. The 45S5 bioglass enhanced stability significantly due to the bond effect of glassy phase between the CaSO4 grains. After immersing for four days in simulated body fluid (SBF), the specimens with 45S5 bioglass could still retain its original shape compared as opposed to specimens without 45S5 bioglass who experienced disintegration. Meanwhile, its compressive strength and fracture toughness increased by 80% and 37%, respectively. Furthermore, the apatite layer was formed on the CaSO4 scaffolds with 45S5 bioglass in SBF, indicating good bioactivity of the scaffolds. In addition, the scaffolds showed good ability to support the osteoblast-like cell adhesion and proliferation. View Full-Text
Keywords: calcium sulfate; 45S5 bioglass; stability; selective laser sintering; scaffolds calcium sulfate; 45S5 bioglass; stability; selective laser sintering; scaffolds

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Shuai, C.; Zhou, J.; Wu, P.; Gao, C.; Feng, P.; Xiao, T.; Deng, Y.; Peng, S. Enhanced Stability of Calcium Sulfate Scaffolds with 45S5 Bioglass for Bone Repair. Materials 2015, 8, 7498-7510.

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