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Correction published on 1 December 2015, see Materials 2015, 8(12), 8147.
Open AccessArticle

Preparation, Characterization and Evaluation of α-Tocopherol Succinate-Modified Dextran Micelles as Potential Drug Carriers

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School of Pharmacy and Life Sciences, Jiujiang University, 320 Xunyang East Road, Jiujiang 332000, China
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School of Chemical and Biological Engneering, Yichun University, 576 Xuefu Road, Yichun 336000, China
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Authors to whom correspondence should be addressed.
Academic Editor: Jung Kwon (John) Oh
Materials 2015, 8(10), 6685-6696; https://doi.org/10.3390/ma8105332
Received: 18 August 2015 / Revised: 13 September 2015 / Accepted: 17 September 2015 / Published: 28 September 2015
(This article belongs to the Section Biomaterials)
In the present study, α-tocopherol succinate (TOS) conjugated dextran (Dex-TOS) was synthesized and characterized by fourier transform infrared (FT-IR) spectroscopy, 1H nuclear magnetic resonance (1H NMR), dynamic light scattering (DLS) and fluorescence spectroscopy. Dex-TOS could form nanoscaled micelles in aqueous medium. The critical micelle concentration (CMC) is 0.0034 mg/mL. Doxorubicin (Dox) was selected as a model drug. Dox-loaded Dex-TOS (Dex-TOS/Dox) micelles were prepared by a dialysis method. The size of Dex-TOS/Dox micelles increased from 295 to 325 nm with the Dox-loading content increasing from 4.21% to 8.12%. The Dex-TOS/Dox micelles were almost spherical in shape, as determined by transmission electron microscopy (TEM). In vitro release demonstrated that Dox release from the micelles was in a sustained manner for up to 96 h. The cellular uptake of Dex-TOS/Dox micelles in human nasopharyngeal epidermoid carcinoma (KB) cells is an endocytic process determined by confocal laser scanning microscopy (CLSM). Moreover, Dex-TOS/Dox micelles exhibited comparable cytotoxicity in contrast with doxorubicin hydrochloride. These results suggested that Dex-TOS micelles could be a promising carrier for drug delivery. View Full-Text
Keywords: dextran; α-tocopherol succinate; polymeric micelles; doxorubicin; drug carrier dextran; α-tocopherol succinate; polymeric micelles; doxorubicin; drug carrier
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Yu, J.; Zhou, Y.; Chen, W.; Ren, J.; Zhang, L.; Lu, L.; Luo, G.; Huang, H. Preparation, Characterization and Evaluation of α-Tocopherol Succinate-Modified Dextran Micelles as Potential Drug Carriers. Materials 2015, 8, 6685-6696.

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