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Materials 2014, 7(9), 6779-6795;

Preparation and Characterization of Injectable Brushite Filled-Poly (Methyl Methacrylate) Bone Cement

Department of Bioengineering, the University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA
Department of Orthopaedic Surgery, University of North Texas Health Science Center (UNTHSC), Fort Worth, TX 76107, USA
Department of Materials Science and Engineering, University of North Texas, Denton, TX 76203, USA
Author to whom correspondence should be addressed.
Received: 4 August 2014 / Revised: 6 September 2014 / Accepted: 15 September 2014 / Published: 19 September 2014
(This article belongs to the Section Biomaterials)
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Powder-liquid poly (methyl methacrylate) (PMMA) bone cements are widely utilized for augmentation of bone fractures and fixation of orthopedic implants. These cements typically have an abundance of beneficial qualities, however their lack of bioactivity allows for continued development. To enhance osseointegration and bioactivity, calcium phosphate cements prepared with hydroxyapatite, brushite or tricalcium phosphates have been introduced with rather unsuccessful results due to increased cement viscosity, poor handling and reduced mechanical performance. This has limited the use of such cements in applications requiring delivery through small cannulas and in load bearing. The goal of this study is to design an alternative cement system that can better accommodate calcium-phosphate additives while preserving cement rheological properties and performance. In the present work, a number of brushite-filled two-solution bone cements were prepared and characterized by studying their complex viscosity-versus-test frequency, extrusion stress, clumping tendency during injection through a syringe, extent of fill of a machined void in cortical bone analog specimens, and compressive strength. The addition of brushite into the two-solution cement formulations investigated did not affect the pseudoplastic behavior and handling properties of the materials as demonstrated by rheological experiments. Extrusion stress was observed to vary with brushite concentration with values lower or in the range of control PMMA-based cements. The materials were observed to completely fill pre-formed voids in bone analog specimens. Cement compressive strength was observed to decrease with increasing concentration of fillers; however, the materials exhibited high enough strength for consideration in load bearing applications. The results indicated that partially substituting the PMMA phase of the two-solution cement with brushite at a 40% by mass concentration provided the best combination of the properties investigated. This alternative material may find applications in systems requiring highly injectable and viscous cements such as in the treatment of spinal fractures and bone defects. View Full-Text
Keywords: Poly (methyl methacrylate) bone cement; polymer composites; calcium phosphate; complex viscosity; rheology; compressive strength Poly (methyl methacrylate) bone cement; polymer composites; calcium phosphate; complex viscosity; rheology; compressive strength

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Rodriguez, L.C.; Chari, J.; Aghyarian, S.; Gindri, I.M.; Kosmopoulos, V.; Rodrigues, D.C. Preparation and Characterization of Injectable Brushite Filled-Poly (Methyl Methacrylate) Bone Cement. Materials 2014, 7, 6779-6795.

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