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Synthesis and Phase Behavior of Poly(N-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(N-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride)

1
Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
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Department of Pathology and Medical Biology, Section of Immunoendocrinology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EA11, 9700 RB Groningen, The Netherlands
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Author to whom correspondence should be addressed.
Materials 2014, 7(7), 5305-5326; https://doi.org/10.3390/ma7075305
Received: 7 May 2014 / Revised: 8 July 2014 / Accepted: 17 July 2014 / Published: 22 July 2014
The synthesis of poly(N-isopropylacrylamide)-b-poly(L-lysine) and poly(N- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of N-isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~80%). Lower yields (~50%) were observed when narrowly dispersed random copolymers of N-isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide- co-acrylamide) were successfully used as macroinitiators for ROP of N6-carbobenzoxy-L- lysine N-carboxyanhydride. The thermal behavior of the homopolymers and copolymers in aqueous solutions was studied by turbidimetry, dynamic light scattering (DLS) and proton nuclear magnetic resonance spectroscopy (1H-NMR). View Full-Text
Keywords: diblock copolymers; ATRP; ROP; thermal behavior diblock copolymers; ATRP; ROP; thermal behavior
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Spasojević, M.; Vorenkamp, J.; Jansen, M.R.P.A.C.S.; De Vos, P.; Schouten, A.J. Synthesis and Phase Behavior of Poly(N-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(N-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride). Materials 2014, 7, 5305-5326.

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