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Preparation of Multifunctional [email protected] Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
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Materials 2014, 7(2), 653-661; https://doi.org/10.3390/ma7020653
Received: 18 November 2013 / Revised: 26 November 2013 / Accepted: 16 January 2014 / Published: 24 January 2014
(This article belongs to the Section Biomaterials)
Iron core gold shell nanoparticles grafted with Methotrexate (MTX) and indocyanine green (ICG) were synthesized for the first time in this study, and preliminarily evaluated for their potential in magnetic hyperthermia treatment. The core-shell [email protected] nanoparticles were prepared via the microemulsion process and then grafted with MTX and ICG using hydrolyzed poly(styrene-alt-maleic acid) (PSMA) to obtain core-shell [email protected]/MTX nanoparticles. MTX is an anti-cancer therapeutic, and ICG is a fluorescent dye. XRD, TEM, FTIR and UV-Vis spectrometry were performed to characterize the nanoparticles. The data indicated that the average size of the nanoparticles was 6.4 ± 09 nm and that the Au coating protected the Fe core from oxidation. MTX and ICG were successfully grafted onto the surface of the nanoparticles. Under exposure to high frequency induction waves, the superparamagnetic nanoparticles elevated the temperature of a solution in a few minutes, which suggested the potential for an application in magnetic hyperthermia treatment. The in vitro studies verified that the nanoparticles were biocompatible; nonetheless, the [email protected]/MTX nanoparticles killed cancer cells (Hep-G2) via the magnetic hyperthermia mechanism and the release of MTX. View Full-Text
Keywords: methotrexate; indocyanine green; core-shell [email protected]/MTX nanoparticles; magnetic hyperthermia treatment; in vitro studies methotrexate; indocyanine green; core-shell [email protected]/MTX nanoparticles; magnetic hyperthermia treatment; in vitro studies
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Chung, R.-J.; Shih, H.-T. Preparation of Multifunctional [email protected] Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia. Materials 2014, 7, 653-661.

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