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Synthesis, Structural Characterization, and Antitumor Activity of a Ca(II) Coordination Polymer Based on 1,6-Naphthalenedisulfonate and 4,4′-Bipyridyl

by Xishi Tai 1,* and Wenhua Zhao 2
1
College of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, China
2
Department of Chemistry, Qinghai Normal University, Xining 810008, Qinghai Province, China
*
Author to whom correspondence should be addressed.
Materials 2013, 6(8), 3547-3555; https://doi.org/10.3390/ma6083547
Received: 27 June 2013 / Revised: 12 July 2013 / Accepted: 7 August 2013 / Published: 16 August 2013
(This article belongs to the Section Biomaterials)
A novel Ca(II) coordination polymer, [CaL(4,4′-bipyridyl)(H2O)4]n (L = 1,6-naphthalenedisulfonate), was synthesized by reaction of calcium perchlorate with 1,6-naphthalenedisulfonic acid disodium salt and 4,4′-bipyridyl in CH3CH2OH/H2O. It was characterized by elemental analysis, IR, molar conductivity and thermogravimetric analysis. X-ray crystallography reveals that the Ca(II) coordination polymer belongs to the orthorhombic system, with space group P212121. The geometry of the Ca(II) ion is a distorted CaNO6 pengonal bipyramid, arising from its coordination by four water molecules, one nitrogen atom of 4,4′-bipyridyl molecule, and two oxygen atoms from two L ligands. The complex molecules form a helical chain by self-assembly. The antitumor activity of 1,6-naphthalenedisulfonic acid disodium salt and the Ca(II) coordination polymer against human hepatoma smmc-7721 cell line and human lung adenocarcinoma A549 cell line reveals that the Ca(II) coordination polymer inhibits cell growth of human lung adenocarcinoma A549 cell line with IC50 value of 27 μg/mL, and is more resistive to human lung adenocarcinoma A549 cell line as compared to 1,6-naphthalenedisulfonic acid disodium salt. View Full-Text
Keywords: Ca(II) coordination polymer; synthesis; structural characterization; antitumor activity Ca(II) coordination polymer; synthesis; structural characterization; antitumor activity
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Tai, X.; Zhao, W. Synthesis, Structural Characterization, and Antitumor Activity of a Ca(II) Coordination Polymer Based on 1,6-Naphthalenedisulfonate and 4,4′-Bipyridyl. Materials 2013, 6, 3547-3555.

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