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Open AccessArticle

A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and in Silico Disposition for Controlled Drug Release

1
Faculty of Health Sciences, Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
2
Faculty of Health Sciences, Division of Neurosciences, Department of Neurology, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
*
Author to whom correspondence should be addressed.
Materials 2013, 6(10), 4284-4308; https://doi.org/10.3390/ma6104284
Received: 4 July 2013 / Revised: 13 August 2013 / Accepted: 16 August 2013 / Published: 26 September 2013
(This article belongs to the Special Issue Smart Polymers and Polymeric Structures)
The rheological behavioral changes that occurred during the synthesis of an interpolyelectrolyte complex (IPEC) of methacrylate copolymer and sodium carboxymethylcellulose were assessed. These changes were compared with the rheological behavior of the individual polymers employing basic viscosity, yield stress, stress sweep, frequency sweep, temperature ramp as well as creep and recovery testing. The rheological studies demonstrated that the end-product of the complexation of low viscous methacrylate copolymer and entangled solution of sodium carboxymethylcellulose generated a polymer, which exhibited a solid-like behavior with a three-dimensional network. Additionally, the rheological profile of the sodium carboxymethylcellulose and methacrylate copolymer with respect to the effect of various concentrations of acetic acid on the synthesis of the IPEC was elucidated using molecular mechanics energy relationships (MMER) by exploring the spatial disposition of carboxymethylcellulose and methacrylate copolymer with respect to each other and acetic acid. The computational results corroborated well with the experimental in vitro drug release data. Results have shown that the IPEC may be suitable polymeric material for achieving controlled zero-order drug delivery. View Full-Text
Keywords: interpolyelectrolyte complex; eudragit; carboxymethylcellulose; rheology; hydrogel; molecular mechanics interpolyelectrolyte complex; eudragit; carboxymethylcellulose; rheology; hydrogel; molecular mechanics
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Ngwuluka, N.C.; Choonara, Y.E.; Kumar, P.; Modi, G.; Toit, L.C.; Pillay, V. A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and in Silico Disposition for Controlled Drug Release. Materials 2013, 6, 4284-4308.

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