Next Article in Journal / Special Issue
Migration Capacity and Viability of Human Primary Osteoblasts in Synthetic Three-dimensional Bone Scaffolds Made of Tricalciumphosphate
Previous Article in Journal
Defects Identification and Effects of Annealing on Lu2(1-x)Y2xSiO5 (LYSO) Single Crystals for Scintillation Application
Previous Article in Special Issue
Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
Article Menu

Export Article

Open AccessArticle
Materials 2011, 4(7), 1238-1248;

Influence of Surface Processing on the Biocompatibility of Titanium

Ear, Nose, and Throat Department, University of Regensburg, Regensburg 93042, Germany
Cardiothoracic Surgery Department, University of Regensburg, Regensburg 93042, Germany
Ear, Nose, and Throat Department, Sørlandet Sykehus, Kristiansand N-4600, Norway
Author to whom correspondence should be addressed.
Received: 5 May 2011 / Accepted: 27 June 2011 / Published: 6 July 2011
(This article belongs to the Special Issue Advances in Biomaterials 2011)
Full-Text   |   PDF [859 KB, uploaded 6 July 2011]   |  


Surface conditioning of titanium middle ear implants results in an improved biocompatibility, which can be characterized by the properties of fibroblasts cultured on conditioned surfaces. Titanium has been established as a favorable biomaterial in ossicular chain reconstruction. The epithelization of the surface of the implants is important for their integration and stable positioning in the middle ear. Mouse fibroblast cells were cultured on platelets made from pure Grade 2 titanium. Platelets that had been etched along their production process were compared to unetched platelets. The DNA in the cell nuclei was stained with DAPI and the actin filaments of the cytoskeleton were stained with FITC-conjugated phalloidin in order to analyze the cells grown on etched and unetched platelets by fluorescence microscopy. SEM (scanning electron microscopic) images were used to compare the surface structure of etched and unetched titanium platelets. There was a statistically significant increase of the area covered by the cytoplasm and increased actin expression by fibroblasts grown on the etched titanium platelets. In addition, the area of the platelets covered by nuclei on the etched platelets exceeded on average the one on unetched platelets, although this difference was not significant. The SEM pictures comparing unetched and etched titanium platelets showed a clear difference in surface structure. Surface conditioning of titanium implants improved the epithelization by fibroblasts and consequently etched titanium should be the preferred biomaterial for reconstructive middle ear surgery. View Full-Text
Keywords: biocompatibility; Titanium surface processing; Titanium ossicular implant; Kurz biocompatibility; Titanium surface processing; Titanium ossicular implant; Kurz

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Wirsching, K.; Lehle, K.; Jacob, P.; Gleich, O.; Strutz, J.; Kwok, P. Influence of Surface Processing on the Biocompatibility of Titanium. Materials 2011, 4, 1238-1248.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top