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Magnesium-Based Alloys Used in Orthopedic Surgery

1
Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania
2
Academy of Romanian Scientista, 54 Splaiul Independentei, 050094 Bucharest, Romania
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Faculty of Electrical Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania
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Medical Ortovit Ltd., 8 Miron Costin Street, 011098 Bucharest, Romania
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Faculty of Medicine and Pharmacy, University Dunarea de Jos Galati, 35 Alexandru Ioan Cuza Street, 800010 Galati, Romania
*
Authors to whom correspondence should be addressed.
Academic Editors: Chao Xu and Jing Zuo
Materials 2022, 15(3), 1148; https://doi.org/10.3390/ma15031148
Received: 18 December 2021 / Revised: 27 January 2022 / Accepted: 29 January 2022 / Published: 2 February 2022
(This article belongs to the Special Issue Study on the Development and Applications of Magnesium Alloys)
Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval. View Full-Text
Keywords: Mg-based alloys; orthopedy; biomaterials; mechanical properties; clinical translation; biocompatibility Mg-based alloys; orthopedy; biomaterials; mechanical properties; clinical translation; biocompatibility
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MDPI and ACS Style

Antoniac, I.; Miculescu, M.; Mănescu, V.; Stere, A.; Quan, P.H.; Păltânea, G.; Robu, A.; Earar, K. Magnesium-Based Alloys Used in Orthopedic Surgery. Materials 2022, 15, 1148. https://doi.org/10.3390/ma15031148

AMA Style

Antoniac I, Miculescu M, Mănescu V, Stere A, Quan PH, Păltânea G, Robu A, Earar K. Magnesium-Based Alloys Used in Orthopedic Surgery. Materials. 2022; 15(3):1148. https://doi.org/10.3390/ma15031148

Chicago/Turabian Style

Antoniac, Iulian, Marian Miculescu, Veronica Mănescu, Alexandru Stere, Pham Hong Quan, Gheorghe Păltânea, Alina Robu, and Kamel Earar. 2022. "Magnesium-Based Alloys Used in Orthopedic Surgery" Materials 15, no. 3: 1148. https://doi.org/10.3390/ma15031148

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