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Review

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

1
Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdańsk, Poland
2
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK 73104, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Eun-Kyung Lim
Materials 2021, 14(9), 2135; https://doi.org/10.3390/ma14092135
Received: 1 March 2021 / Revised: 15 April 2021 / Accepted: 20 April 2021 / Published: 22 April 2021
Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients’ recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery, simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010–2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field. View Full-Text
Keywords: doxorubicin; drug delivery; polymers; targeted therapy; anticancer treatment; controlled release doxorubicin; drug delivery; polymers; targeted therapy; anticancer treatment; controlled release
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MDPI and ACS Style

Butowska, K.; Woziwodzka, A.; Borowik, A.; Piosik, J. Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies. Materials 2021, 14, 2135. https://doi.org/10.3390/ma14092135

AMA Style

Butowska K, Woziwodzka A, Borowik A, Piosik J. Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies. Materials. 2021; 14(9):2135. https://doi.org/10.3390/ma14092135

Chicago/Turabian Style

Butowska, Kamila, Anna Woziwodzka, Agnieszka Borowik, and Jacek Piosik. 2021. "Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies" Materials 14, no. 9: 2135. https://doi.org/10.3390/ma14092135

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