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DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors

1
Photonic Nanosystems, Department of Physics, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 3, PER08, 1700 Fribourg, Switzerland
2
Laboratory of Experimental and Translational Oncology, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 18, PER17, 1700 Fribourg, Switzerland
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Materials 2020, 13(9), 2185; https://doi.org/10.3390/ma13092185
Received: 7 April 2020 / Revised: 30 April 2020 / Accepted: 5 May 2020 / Published: 9 May 2020
(This article belongs to the Special Issue Advances in Bio-Inspired Materials for Medical Applications)
DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex devices with precise and predictable structural characteristics. Combined with the addressability and flexibility of the chemistry for DNA functionalization, DNA origami allows the precise design of sensors capable of detecting a large range of different targets, encompassing RNA, DNA, proteins, small molecules, or changes in physico-chemical parameters, that could serve as diagnostic tools. Here, we review some recent, salient developments in DNA origami-based sensors centered on optical detection methods (readout) with a special emphasis on the sensitivity, the selectivity, and response time. We also discuss challenges that still need to be addressed before this approach can be translated into robust diagnostic devices for bio-medical applications. View Full-Text
Keywords: DNA nanotechnology; DNA origami; biosensors; optics (plasmonic and fluorescence sensing) DNA nanotechnology; DNA origami; biosensors; optics (plasmonic and fluorescence sensing)
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Loretan, M.; Domljanovic, I.; Lakatos, M.; Rüegg, C.; Acuna, G.P. DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors. Materials 2020, 13, 2185.

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