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Open AccessArticle

Fabrication of Bioprobe Self-Assembled on Au–Te Nanoworm Structure for SERS Biosensor

1
Department of Chemical Engineering, Kwangwoon University, Seoul 01897, Korea
2
Department of Chemistry, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea
3
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Materials 2020, 13(14), 3234; https://doi.org/10.3390/ma13143234
Received: 16 June 2020 / Revised: 17 July 2020 / Accepted: 17 July 2020 / Published: 21 July 2020
(This article belongs to the Special Issue Application of Nanoparticles as Biosensors in the Biomedical Field)
In the present study, we propose a novel biosensor platform using a gold-tellurium (Au–Te) nanoworm structure through surface-enhanced Raman spectroscopy (SERS). Au–Tenanoworm was synthesized by spontaneous galvanic replacement of sacrificial Te nanorods templated with Au (III) cations under ambient conditions. The fabricated Au–Te nanoworm exhibited an interconnected structure of small spherical nanoparticles and was found to be effective at enhancing Raman scattering. The Au–Te nanoworm-immobilized substrate exhibited the ability to detect thyroxine using an aptamer-tagged DNA three-way junction (3WJ) and glycoprotein 120 (GP120) human immunodeficiency virus (HIV) using an antibody. The modified substrates were investigated by scanning electron microscopy and atomic force microscopy (AFM). The optimal Au–Te nanoworm concentration and immobilization time for the thyroxine biosensor platform were further determined by SERS experimentation. Thus, the present study showed that the Au–Te nanoworm structure could be applied to various biosensor platforms. View Full-Text
Keywords: surface-enhanced Raman spectroscopy; aptamer; antibody; Au–Te nanoworm; biosensor surface-enhanced Raman spectroscopy; aptamer; antibody; Au–Te nanoworm; biosensor
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MDPI and ACS Style

Kim, S.M.; Lee, T.; Gil, Y.-G.; Kim, G.H.; Park, C.; Jang, H.; Min, J. Fabrication of Bioprobe Self-Assembled on Au–Te Nanoworm Structure for SERS Biosensor. Materials 2020, 13, 3234. https://doi.org/10.3390/ma13143234

AMA Style

Kim SM, Lee T, Gil Y-G, Kim GH, Park C, Jang H, Min J. Fabrication of Bioprobe Self-Assembled on Au–Te Nanoworm Structure for SERS Biosensor. Materials. 2020; 13(14):3234. https://doi.org/10.3390/ma13143234

Chicago/Turabian Style

Kim, Soo M.; Lee, Taek; Gil, Yeong-Gyu; Kim, Ga H.; Park, Chulhwan; Jang, Hongje; Min, Junhong. 2020. "Fabrication of Bioprobe Self-Assembled on Au–Te Nanoworm Structure for SERS Biosensor" Materials 13, no. 14: 3234. https://doi.org/10.3390/ma13143234

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