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Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo

1,2, 1,2, 1,2,3, 4, 1,2, 1,2, 1,2, 1,2, 3,* and 1,2,3,*
State key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Shenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China
Authors to whom correspondence should be addressed.
Materials 2019, 12(13), 2191;
Received: 21 May 2019 / Revised: 3 July 2019 / Accepted: 3 July 2019 / Published: 8 July 2019
(This article belongs to the Special Issue Advanced Materials in Drug Release and Drug Delivery Systems)
PDF [2523 KB, uploaded 8 July 2019]


Fluorescence imaging offers a new approach to visualize real-time details on a cellular level in vitro and in vivo without radioactive damage. Poor light stability of organic fluorescent dyes makes long-term imaging difficult. Due to their outstanding optical properties and unique structural features, graphene quantum dots (GQDs) are promising in the field of imaging for real-time tracking in vivo. At present, GQDs are mainly loaded on the surface of nanoparticles. In this study, we developed an efficient and convenient one-pot method to load GQDs into nanoparticles, leading to longer metabolic processes in blood and increased delivery of GQDs to tumors. Optical-magneto ferroferric [email protected] (Fe3O4@PPy) core-shell nanoparticles were chosen for their potential use in cancer therapy. The in vivo results demonstrated that by loading GQDs, it was possible to monitor the distribution and metabolism of nanoparticles. This study provided new insights into the application of GQDs in long-term in vivo real-time tracking. View Full-Text
Keywords: GQDs; real-time tracking; optical-magneto nanoparticles; in vivo GQDs; real-time tracking; optical-magneto nanoparticles; in vivo

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Wang, Y.; Xu, N.; He, Y.; Wang, J.; Wang, D.; Gao, Q.; Xie, S.; Li, Y.; Zhang, R.; Cai, Q. Loading Graphene Quantum Dots into Optical-Magneto Nanoparticles for Real-Time Tracking In Vivo. Materials 2019, 12, 2191.

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