Next Article in Journal
Investigation of Helium Behavior in RAFM Steel by Positron Annihilation Doppler Broadening and Thermal Desorption Spectroscopy
Next Article in Special Issue
Ring Wrinkle Patterns with Continuously Changing Wavelength Produced Using a Controlled-Gradient Light Field
Previous Article in Journal
Treatment Technology of Hazardous Water Contaminated with Radioisotopes with Paper Sludge Ash-Based Geopolymer—Stabilization of Immobilization of Strontium and Cesium by Mixing Seawater
Previous Article in Special Issue
Surface-Attached Poly(oxanorbornene) Hydrogels with Antimicrobial and Protein-Repellent Moieties: The Quest for Simultaneous Dual Activity
Open AccessArticle

Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs

Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15222 Białystok, Poland
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(9), 1522; https://doi.org/10.3390/ma11091522
Received: 18 July 2018 / Revised: 20 August 2018 / Accepted: 21 August 2018 / Published: 24 August 2018
(This article belongs to the Special Issue Polymeric Materials: Surfaces, Interfaces and Bioapplications)
Alginate (ALG) cross-linking by CaCl2 is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl2 cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of water-soluble drugs and a difficulty in controlling the process. Hence, this study presents a novel method that streamlines microparticle production by spray drying; a rapid, continuous, reproducible, and scalable technique enabling obtainment of a product with low moisture content, high drug loading, and a high production yield. To model a freely water-soluble drug, metformin hydrochloride (MF) was selected. It was observed that MF was successfully encapsulated in alginate microparticles cross-linked by CaCl2 using a one-step drying process. Modification of ALG provided drug release prolongation—particles obtained from 2% ALG cross-linked by 0.1% CaCl2 with a prolonged MF rate of dissolution of up to 12 h. Cross-linking of the ALG microparticles structure by CaCl2 decreased the swelling ratio and improved the mucoadhesive properties which were evaluated using porcine stomach mucosa. View Full-Text
Keywords: polymer cross-linking; alginate modification; calcium chloride; microparticles; spray drying; prolonged drug release polymer cross-linking; alginate modification; calcium chloride; microparticles; spray drying; prolonged drug release
Show Figures

Graphical abstract

MDPI and ACS Style

Szekalska, M.; Sosnowska, K.; Czajkowska-Kośnik, A.; Winnicka, K. Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs. Materials 2018, 11, 1522.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop