Next Article in Journal
Grain Refinement and Aging Hardening of the Mg-10Gd-3Y-2Ag-0.4Zr Alloy Produced by a Two-Step Forming Process
Next Article in Special Issue
Development of a Novel in Silico Model to Investigate the Influence of Radial Clearance on the Acetabular Cup Contact Pressure in Hip Implants
Previous Article in Journal
New Magnetostrictive Transducer Designs for Emerging Application Areas of NDE
Previous Article in Special Issue
Experimentally Achievable Accuracy Using a Digital Image Correlation Technique in measuring Small-Magnitude (<0.1%) Homogeneous Strain Fields
Open AccessArticle

Macrophage Biocompatibility of CoCr Wear Particles Produced under Polarization in Hyaluronic Acid Aqueous Solution

Cell-Biomaterial Recognition Lab., Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain
Department of Surface Engineering, Corrosion and Durability, Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC), Avda. Gregorio del Amo 8, 28040 Madrid, Spain
Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California Los Angeles, Orthopaedic Hospital Research Center, 615 Charles E. Young Dr. South, Room 450A, Los Angeles, CA 90095 USA
Author to whom correspondence should be addressed.
Materials 2018, 11(5), 756;
Received: 15 March 2018 / Revised: 26 April 2018 / Accepted: 2 May 2018 / Published: 8 May 2018
Macrophages are the main cells involved in inflammatory processes and in the primary response to debris derived from wear of implanted CoCr alloys. The biocompatibility of wear particles from a high carbon CoCr alloy produced under polarization in hyaluronic acid (HA) aqueous solution was evaluated in J774A.1 mouse macrophages cultures. Polarization was applied to mimic the electrical interactions observed in living tissues. Wear tests were performed in a pin-on-disk tribometer integrating an electrochemical cell in phosphate buffer solution (PBS) and in PBS supplemented with 3 g/L HA, an average concentration that is generally found in synovial fluid, used as lubricant solution. Wear particles produced in 3 g/L HA solution showed a higher biocompatibility in J774A.1 macrophages in comparison to those elicited by particles obtained in PBS. A considerable enhancement in macrophages biocompatibility in the presence of 3 g/L of HA was further observed by the application of polarization at potentials having current densities typical of injured tissues suggesting that polarization produces an effect on the surface of the metallic material that leads to the production of wear particles that seem to be macrophage-biocompatible and less cytotoxic. The results showed the convenience of considering the influence of the electric interactions in the chemical composition of debris detached from metallic surfaces under wear corrosion to get a better understanding of the biological effects caused by the wear products. View Full-Text
Keywords: polarization; CoCr alloy; wear particles; hyaluronic acid; macrophages biocompatibility polarization; CoCr alloy; wear particles; hyaluronic acid; macrophages biocompatibility
Show Figures

Figure 1

MDPI and ACS Style

Perez-Maceda, B.T.; López-Fernández, M.E.; Díaz, I.; Kavanaugh, A.; Billi, F.; Escudero, M.L.; García-Alonso, M.C.; Lozano, R.M. Macrophage Biocompatibility of CoCr Wear Particles Produced under Polarization in Hyaluronic Acid Aqueous Solution. Materials 2018, 11, 756.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop