Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study
Abstract
1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ALL | AKI-no | AKI | p | |
---|---|---|---|---|
N | 21 | 12 | 9 | |
Age | 60.9 ± 18.7 | 56.1 ± 19.5 | 67.3 ± 16.4 | 0.179 |
Sex M | 14 (67) | 7 (58) | 7 (78) | |
Sex F | 7 (33) | 5 (42) | 2 (22) | |
Medical ICU diagnosis | 9 (43) | 3 (25) | 6 (67) | |
ICU Postoperative management | 12 (57) | 9 (75) | 3 (33) | |
SAPS II | 45.8 ± 10.4 | 39.1 ± 7.3 | 54.6 ± 6.6 | 0.0001 |
SOFA T0 | 11.4 ± 2.6 | 10.4 ± 2.5 | 12.7 ± 2.3 | 0.046 |
SOFA T1 | 11.7 ± 2.6 | 10.7 ± 2.4 | 13.1 ± 2.3 | 0.038 |
SOFA T2 | 11.2 ± 2.9 | 10.2 ± 3.1 | 12.6 ± 2.2 | 0.065 |
sCr T0 (mg/dL) | 1.35 ± 1.05 | 0.76 ± 0.23 | 2.1 ± 1.8 | 0.012 |
Renal length T0 (cm) | 10.4 ± 1.4 | 11.5 ± 1.1 | 9.5 ± 1.1 | 0.001 |
MAP T0 (mmHg) | 98.9 ± 12.7 | 103.6 ± 7.9 | 92.7 ± 15.5 | 0.079 |
PEEP T0 (cmH2O) | 6.1 ± 5.6 | 5.9 ± 6.5 | 6.4 ± 4.6 | 1.00 |
AKI | AKI–NO | p | AUC ROC (95% CI) | p | CUT-OFF | SENSITIVITY (95% CI) | SPECIFICITY (95% CI) | |
---|---|---|---|---|---|---|---|---|
SCR (MG/DL) T0 | 2.1 ± 1.8 | 0.76 ± 0.23 | 0.012 | 0.83 (0.60–0.99) | 0.013 | 1.2 | 75% | 99% |
UNGAL (NG/ML) T0 | 387.9 ± 37.7 | 20.9 ± 12.7 | 0.0001 | 0.93 (0.78–0.99) | 0.001 | 131.7 | 78% | 99% |
RRI T0 | 0.67 ± 0.12 | 0.63 ± 0.07 | 0.464 | 0.60 (0.32–0.90) | 0.456 | 0.70 | 57% | 85% |
RENAL LENGTH T0 (CM) | 9.5 ± 1.1 | 11.5 ± 1.1 | 0.001 | 0.917 (0.71–0.99) | <0.0001 | 10.03 | 100 | 88.9 |
MDRD | 64 ± 72.5 | 106.9 ± 39.2 | 0.097 | 0.796 (0.56–0.93) | 0.0229 | 53 | 77.8 | 91.7 |
SAPS II | 54.6 ± 6.6 | 39.1 ± 7.3 | 0.0001 | 0.940 (0.74–0.99) | <0.0001 | 46 | 88.9 | 83.3 |
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Brogi, E.; Rago, R.; Forfori, F. Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study. Pathophysiology 2024, 31, 190-196. https://doi.org/10.3390/pathophysiology31020015
Brogi E, Rago R, Forfori F. Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study. Pathophysiology. 2024; 31(2):190-196. https://doi.org/10.3390/pathophysiology31020015
Chicago/Turabian StyleBrogi, Etrusca, Rocco Rago, and Francesco Forfori. 2024. "Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study" Pathophysiology 31, no. 2: 190-196. https://doi.org/10.3390/pathophysiology31020015
APA StyleBrogi, E., Rago, R., & Forfori, F. (2024). Evaluation of Renal Function with Urinary NGAL and Doppler Ultrasonography in ICU Patients: A 1-Year Observational Pilot Study. Pathophysiology, 31(2), 190-196. https://doi.org/10.3390/pathophysiology31020015