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Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration’s Reassessment and Uptake Working Group

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Temerty Faculty of Medicine, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada
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Canadian Centre for Applied Research in Cancer Control, Toronto, ON M5G 2L3, Canada
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New Brunswick Cancer Network, Saint John, NB E2J 3S4, Canada
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Canadian Agency for Drugs and Technologies in Health, Ottawa, ON K1S 5S8, Canada
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Ontario Health (CCO), Toronto, ON M5G 2L7, Canada
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Saskatchewan Cancer Agency, Regina, SK S4W 0G3, Canada
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Patented Medicine Prices Review Board, Ottawa, ON K1P 1C1, Canada
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Government of Manitoba, Winnipeg, MB R3B 3M9, Canada
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Alberta Health Services, Edmonton, AB T5J 3E4, Canada
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Health Canada, Ottawa, ON K1Y 4X2, Canada
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Canadian Association of Provincial Cancer Agencies, Toronto, ON M5H 1J9, Canada
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Department of Medicine, Dalhousie University, Halifax, NS B3H 2Y9, Canada
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Department of Biology, University of New Brunswick, Fredericton, NB E3B 5A3, Canada
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Department of Oncology, Saint John Regional Hospital, Saint John, NB E2L 42L, Canada
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The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
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Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada
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Women’s College Hospital, Toronto, ON M5S 1B2, Canada
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Author to whom correspondence should be addressed.
Wei Fang Dai and Vanessa Arciero contributed equally to this work.
Membership of the CanREValue Collaboration Reassessment and Uptake Working Group is provided in the Acknowledgments.
Curr. Oncol. 2021, 28(5), 4174-4183; https://doi.org/10.3390/curroncol28050354
Received: 28 August 2021 / Revised: 4 October 2021 / Accepted: 4 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Access to Cancer Drugs in Canada)
The Canadian Real-world Evidence for Value in Cancer Drugs (CanREValue) Collaboration was established to develop a framework for generating and using real-world evidence (RWE) to inform the reassessment of cancer drugs following initial health technology assessment (HTA). The Reassessment and Uptake Working Group (RWG) is one of the five established CanREValue Working Groups. The RWG aims to develop considerations for incorporating RWE for HTA reassessment and strategies for using RWE to reassess drug funding decisions. Between February 2018 and December 2019, the RWG attended four teleconferences (with follow-up surveys) and two in-person meetings to discuss recommendations for the development of a reassessment process and potential barriers and facilitators. Modified Delphi methods were used to gather input. A draft report of recommendations (to December 2018) was shared for public consultation (December 2019 to January 2020). Initial considerations for developing a reassessment process were proposed. Specifically, reassessment can be initiated by diverse stakeholders, including decision makers from public drug plans or industry stakeholders. The reassessment process should be modelled after existing deliberation and recommendation frameworks used by HTA agencies. Proposed reassessment outcome categories include maintaining status quo, revisiting funding criteria, renegotiating price, or disinvesting. Overall, these initial considerations will serve as the basis for future advancements by the Collaboration. View Full-Text
Keywords: health technology assessment; real-world evidence; reassessment health technology assessment; real-world evidence; reassessment
MDPI and ACS Style

Dai, W.F.; Arciero, V.; Craig, E.; Fraser, B.; Arias, J.; Boehm, D.; Bosnic, N.; Caetano, P.; Chambers, C.; Jones, B.; Lungu, E.; Mitera, G.; Potashnik, T.; Reiman, A.; Ritcher, T.; Beca, J.M.; Denburg, A.; Mercer, R.E.; Parmar, A.; Tadrous, M.; Takhar, P.; Chan, K.K.W.; on behalf of the CanREValue Collaboration Reassessment and Uptake Working Group. Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration’s Reassessment and Uptake Working Group. Curr. Oncol. 2021, 28, 4174-4183. https://doi.org/10.3390/curroncol28050354

AMA Style

Dai WF, Arciero V, Craig E, Fraser B, Arias J, Boehm D, Bosnic N, Caetano P, Chambers C, Jones B, Lungu E, Mitera G, Potashnik T, Reiman A, Ritcher T, Beca JM, Denburg A, Mercer RE, Parmar A, Tadrous M, Takhar P, Chan KKW, on behalf of the CanREValue Collaboration Reassessment and Uptake Working Group. Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration’s Reassessment and Uptake Working Group. Current Oncology. 2021; 28(5):4174-4183. https://doi.org/10.3390/curroncol28050354

Chicago/Turabian Style

Dai, Wei F., Vanessa Arciero, Erica Craig, Brent Fraser, Jessica Arias, Darryl Boehm, Nevzeta Bosnic, Patricia Caetano, Carole Chambers, Barry Jones, Elena Lungu, Gunita Mitera, Tanya Potashnik, Anthony Reiman, Trevor Ritcher, Jaclyn M. Beca, Avram Denburg, Rebecca E. Mercer, Ambica Parmar, Mina Tadrous, Pam Takhar, Kelvin K.W. Chan, and on behalf of the CanREValue Collaboration Reassessment and Uptake Working Group. 2021. "Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration’s Reassessment and Uptake Working Group" Current Oncology 28, no. 5: 4174-4183. https://doi.org/10.3390/curroncol28050354

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