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Current Oncology
Volume 27
Issue 4
10.3747/co.27.6557
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cell Carcinoma: A Rare Presentation of an Uncommon Cancer

by
Az. Saeed
1,*,
Z.U. Hameem
2,
D. Modi
2,
R. Park
3 and
An. Saeed
2
1
Department of Medicine, Division of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA
2
Department of Medicine, Division of Medical Oncology, Kansas University Medical Center, Kansas City, KS, USA
3
Department of Medicine, MetroWest Medical Center, Tufts University School of Medicine, Framingham, MA, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2020, 27(4), 433-435; https://doi.org/10.3747/co.27.6557
Submission received: 6 May 2020 / Revised: 9 June 2020 / Accepted: 14 July 2020 / Published: 1 August 2020

Abstract

Paraneoplastic syndromes associated with anal squamous cell carcinoma (scc) are rare. Erythema gyratum repens (egr) is a cutaneous paraneoplastic syndrome with distinctive characteristics. Here, we report the rare case of a 73-year-old woman with a chronic erythematous rash for 11 months associated with intense pruritus. She was treated with prednisone and antihistamines by dermatologists, but did not respond. The patient was subsequently seen in our clinic for unintentional weight loss and anorexia with intermittent nausea and vomiting. During further evaluation with imaging studies, upper endoscopy, and colonoscopy with biopsy, poorly differentiated anal scc was identified. Biopsies of the skin rash were characteristic of egr. She was treated using concurrent chemotherapy with 5-fluorouracil and mitomycin C and pelvic radiation (50.4 Gy in 28 fractions) for anal scc. She tolerated the treatment, and her rash faded, with resolution of the pruritus.
Keywords: paraneoplastic syndrome; anal squamous cell carcinoma; erythema gyratum repens paraneoplastic syndrome; anal squamous cell carcinoma; erythema gyratum repens

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MDPI and ACS Style

Saeed, A.; Hameem, Z.U.; Modi, D.; Park, R.; Saeed, A. Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cell Carcinoma: A Rare Presentation of an Uncommon Cancer. Curr. Oncol. 2020, 27, 433-435. https://doi.org/10.3747/co.27.6557

AMA Style

Saeed A, Hameem ZU, Modi D, Park R, Saeed A. Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cell Carcinoma: A Rare Presentation of an Uncommon Cancer. Current Oncology. 2020; 27(4):433-435. https://doi.org/10.3747/co.27.6557

Chicago/Turabian Style

Saeed, Az., Z.U. Hameem, D. Modi, R. Park, and An. Saeed. 2020. "Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cell Carcinoma: A Rare Presentation of an Uncommon Cancer" Current Oncology 27, no. 4: 433-435. https://doi.org/10.3747/co.27.6557

APA Style

Saeed, A., Hameem, Z. U., Modi, D., Park, R., & Saeed, A. (2020). Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cell Carcinoma: A Rare Presentation of an Uncommon Cancer. Current Oncology, 27(4), 433-435. https://doi.org/10.3747/co.27.6557

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