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Current Oncology
Volume 27
Issue 2
10.3747/co.27.5651
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

A Randomized Trial of the Electronic Lung Cancer Symptom Scale for Quality-of-Life Assessment in Patients with Advanced Non-small-Cell Lung Cancer

by
J.C. Kuo
1,2,
D.M. Graham
1,3,
A. Salvarrey
1,
F. Kassam
1,4,
L.W. Le
1,
F.A. Shepherd
1,
R. Burkes
5,
P.J. Hollen
6,
R.J. Gralla
7 and
N.B. Leighl
1,*
1
Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada
2
University of New South Wales, Sydney, Australia
3
Queen’s University Belfast, Belfast, UK
4
Division of Medical Oncology, Southlake Regional Cancer Centre, Newmarket, ON, Canada
5
Division of Medical Oncology, Mount Sinai Hospital, Toronto, ON, Canada
6
School of Nursing, University of Virginia, Charlottesville, VA, USA
7
Albert Einstein College of Medicine, New York, NY, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2020, 27(2), 156-162; https://doi.org/10.3747/co.27.5651
Submission received: 9 February 2020 / Revised: 8 March 2020 / Accepted: 7 April 2020 / Published: 1 May 2020

Abstract

Introduction: Improving health-related quality of life (hrqol) is a key goal of systemic therapy in advanced lung cancer, although routine assessment remains challenging. We analyzed the impact of a real-time electronic hrqol tool, the electronic Lung Cancer Symptom Scale (elcss-ql), on palliative care (pc) referral rates, patterns of chemotherapy treatment, and use of other supportive interventions in patients with advanced non-small-cell lung cancer (nsclc) receiving first-line chemotherapy. Methods: Patients with advanced nsclc starting first-line chemotherapy were randomized to their oncologist receiving or not receiving their elcss-ql data before each clinic visit. Patients completed the elcss-ql at baseline, before each chemotherapy cycle, and at subsequent follow-up visits until disease progression. Prospective data about the pc referral rate, hrqol, and use of other supportive interventions were collected. Results: For the 95 patients with advanced nsclc who participated, oncologists received real-time elcss-ql data for 44 (elcss-ql arm) and standard clinical assessment alone for 51 (standard arm). The primary endpoint, the pc referral rate, was numerically higher, but statistically similar, for patients in the elcss-ql and standard arms. The hrqol scores over time were not significantly different between the two study arms. Conclusions: The elcss-ql is feasible as a tool for use in routine clinical practice, although no statistically significant effect of its use was demonstrated in our study. Improving access to supportive care through the collection of patient-reported outcomes and hrqol should be an important component of care for patients with advanced lung cancer.
Keywords: patient-reported outcomes; palliative care; supportive care patient-reported outcomes; palliative care; supportive care

Share and Cite

MDPI and ACS Style

Kuo, J.C.; Graham, D.M.; Salvarrey, A.; Kassam, F.; Le, L.W.; Shepherd, F.A.; Burkes, R.; Hollen, P.J.; Gralla, R.J.; Leighl, N.B. A Randomized Trial of the Electronic Lung Cancer Symptom Scale for Quality-of-Life Assessment in Patients with Advanced Non-small-Cell Lung Cancer. Curr. Oncol. 2020, 27, 156-162. https://doi.org/10.3747/co.27.5651

AMA Style

Kuo JC, Graham DM, Salvarrey A, Kassam F, Le LW, Shepherd FA, Burkes R, Hollen PJ, Gralla RJ, Leighl NB. A Randomized Trial of the Electronic Lung Cancer Symptom Scale for Quality-of-Life Assessment in Patients with Advanced Non-small-Cell Lung Cancer. Current Oncology. 2020; 27(2):156-162. https://doi.org/10.3747/co.27.5651

Chicago/Turabian Style

Kuo, J.C., D.M. Graham, A. Salvarrey, F. Kassam, L.W. Le, F.A. Shepherd, R. Burkes, P.J. Hollen, R.J. Gralla, and N.B. Leighl. 2020. "A Randomized Trial of the Electronic Lung Cancer Symptom Scale for Quality-of-Life Assessment in Patients with Advanced Non-small-Cell Lung Cancer" Current Oncology 27, no. 2: 156-162. https://doi.org/10.3747/co.27.5651

APA Style

Kuo, J. C., Graham, D. M., Salvarrey, A., Kassam, F., Le, L. W., Shepherd, F. A., Burkes, R., Hollen, P. J., Gralla, R. J., & Leighl, N. B. (2020). A Randomized Trial of the Electronic Lung Cancer Symptom Scale for Quality-of-Life Assessment in Patients with Advanced Non-small-Cell Lung Cancer. Current Oncology, 27(2), 156-162. https://doi.org/10.3747/co.27.5651

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