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Current Oncology
Volume 27
Issue 1
10.3747/co.27.5953
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Therapeutic Landscape of Metastatic Non-Small-Cell Lung Cancer in Canada in 2020

by
A. Elkrief
1,2,3,
P. Joubert
4,
M. Florescu
3,5,
M. Tehfe
3,5,
N. Blais
3,5 and
B. Routy
3,5,*
1
Segal Cancer Centre, Sir Mortimer B. Davis Jewish General Hospital, Montreal, PQ, Canada
2
Cedars Cancer Centre, McGill University Health Centre, Montreal, PQ, Canada
3
Centre de recherche du Centre hospitalier de l’Universtité de Montréal, Montreal, PQ, Canada
4
Institut universitaire de cardiologie et de pneumologie de Québec, Quebec City, PQ, Canada
5
Division of Hematology-Oncology, Centre hospitalier de l’Université de Montréal, 900 rue St-Denis, Montreal, QC H2X 0A9, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2020, 27(1), 52-60; https://doi.org/10.3747/co.27.5953
Submission received: 12 November 2019 / Revised: 4 December 2019 / Accepted: 11 January 2020 / Published: 1 February 2020

Abstract

Lung cancer is the most commonly diagnosed cancer in Canada and remains associated with high mortality. Nevertheless, recent advances in the fields of immuno-oncology and precision medicine have led to significant improvements in clinical outcome in metastatic non-small-cell lung cancer (nsclc). Those improvements were facilitated by a greater understanding of the biologic classification of nsclc, which catalyzed discoveries of novel therapies. Here, we present a comprehensive review of the recent avalanche of practice-changing trials in metastatic nsclc, and we offer an approach to the management of this disease from a Canadian perspective. We begin with an overview of the pathologic and molecular characterization of metastatic nsclc. Next, we review the indications for currently approved immune checkpoint inhibitors, and we provide an approach to the management of disease with a driver mutation. Finally, we address future avenues in both diagnostics and therapeutics for patients with advanced and metastatic nsclc.
Keywords: lung cancer; immunotherapy; targeted therapy; chemotherapy; biomarkers lung cancer; immunotherapy; targeted therapy; chemotherapy; biomarkers

Share and Cite

MDPI and ACS Style

Elkrief, A.; Joubert, P.; Florescu, M.; Tehfe, M.; Blais, N.; Routy, B. Therapeutic Landscape of Metastatic Non-Small-Cell Lung Cancer in Canada in 2020. Curr. Oncol. 2020, 27, 52-60. https://doi.org/10.3747/co.27.5953

AMA Style

Elkrief A, Joubert P, Florescu M, Tehfe M, Blais N, Routy B. Therapeutic Landscape of Metastatic Non-Small-Cell Lung Cancer in Canada in 2020. Current Oncology. 2020; 27(1):52-60. https://doi.org/10.3747/co.27.5953

Chicago/Turabian Style

Elkrief, A., P. Joubert, M. Florescu, M. Tehfe, N. Blais, and B. Routy. 2020. "Therapeutic Landscape of Metastatic Non-Small-Cell Lung Cancer in Canada in 2020" Current Oncology 27, no. 1: 52-60. https://doi.org/10.3747/co.27.5953

APA Style

Elkrief, A., Joubert, P., Florescu, M., Tehfe, M., Blais, N., & Routy, B. (2020). Therapeutic Landscape of Metastatic Non-Small-Cell Lung Cancer in Canada in 2020. Current Oncology, 27(1), 52-60. https://doi.org/10.3747/co.27.5953

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