Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease

Bernstock, J.D.; Cohen, J.L.; Singh, S.; Schlappi, C.W.; Fiveash, J.B.; Johnston, J.M.; Fequiere, P.; Orr, B.A.; Li, R.; Friedman, G.K.

doi:10.3747/co.26.4491

Open AccessArticle

Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease

by

J.D. Bernstock

^1,†,

J.L. Cohen

^1,†,

S. Singh

²,

C.W. Schlappi

³,

J.B. Fiveash

⁴,

J.M. Johnston

⁵,

P. Fequiere

⁶,

B.A. Orr

⁷,

R. Li

⁸ and

G.K. Friedman

^3,*

¹

Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA

²

Department of Radiology, Children’s of Alabama, University of Alabama at Birmingham, Birmingham, AL, USA

³

Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA

⁴

Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA

⁵

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA

⁶

Department of Pediatrics, Division of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA

⁷

Pathology Department, St. Jude Children’s Research Hospital, Memphis, TN, USA

⁸

Department of Pathology, Children’s of Alabama, Birmingham, AL, USA

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to the present work.

Curr. Oncol. 2019, 26(2), 266-269; https://doi.org/10.3747/co.26.4491

Submission received: 7 January 2019 / Revised: 7 February 2019 / Accepted: 7 March 2019 / Published: 1 April 2019

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Abstract

Charcot–Marie–Tooth (CMT) disease is the most common form of inherited neuropathy. Core features include peripheral neuropathy and secondary axonal degeneration, with a noted distal predominance of limb-muscle wasting, weakness, and sensory loss. Given the significant prevalence of CMT, superimposed neoplastic disease can be encountered within this patient population. Malignancies that are treated with vincristine (a microtubule-targeting agent), even at low doses as part of standard treatment, pose a significant challenge for patients with CMT. Here, we present the case of a child with CMT who was successfully treated for medulloblastoma without vincristine, a standard drug used for treatment of that disease, to avoid the risk of severe debilitating neuropathy. This report is the first of a patient successfully treated for medulloblastoma without vincristine.

Keywords: Charcot–Marie–Tooth; chemotherapy; medulloblastoma; neurotoxicity; radiotherapy; vincristine

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MDPI and ACS Style

Bernstock, J.D.; Cohen, J.L.; Singh, S.; Schlappi, C.W.; Fiveash, J.B.; Johnston, J.M.; Fequiere, P.; Orr, B.A.; Li, R.; Friedman, G.K. Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease. Curr. Oncol. 2019, 26, 266-269. https://doi.org/10.3747/co.26.4491

AMA Style

Bernstock JD, Cohen JL, Singh S, Schlappi CW, Fiveash JB, Johnston JM, Fequiere P, Orr BA, Li R, Friedman GK. Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease. Current Oncology. 2019; 26(2):266-269. https://doi.org/10.3747/co.26.4491

Chicago/Turabian Style

Bernstock, J.D., J.L. Cohen, S. Singh, C.W. Schlappi, J.B. Fiveash, J.M. Johnston, P. Fequiere, B.A. Orr, R. Li, and G.K. Friedman. 2019. "Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease" Current Oncology 26, no. 2: 266-269. https://doi.org/10.3747/co.26.4491

APA Style

Bernstock, J. D., Cohen, J. L., Singh, S., Schlappi, C. W., Fiveash, J. B., Johnston, J. M., Fequiere, P., Orr, B. A., Li, R., & Friedman, G. K. (2019). Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease. Current Oncology, 26(2), 266-269. https://doi.org/10.3747/co.26.4491

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Treatment-Induced Remission of Medulloblastoma Using a Chemotherapeutic Regimen Devoid of Vincristine in a Child with Charcot–Marie–Tooth Disease

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