Next Article in Journal
Moving toward the Elimination of Cervical Cancer: Modelling the Health and Economic Benefits of Increasing Uptake of Human Papillomavirus Vaccines
Previous Article in Journal
Never too Old to Learn New Tricks: Surveying Canadian Health Care Professionals about Learning Needs in Caring for Older Adults with Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 26
Issue 2
10.3747/co.26.4393
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

A Network Approach to Developing Immuno-Oncology Combinations in Canada

by
V. Higenell
1,
R. Fajzel
1,
G. Batist
1,2,
P.K. Cheema
3,
H.L. McArthur
4,
B. Melosky
5,
D. Morris
6,
T.M. Petrella
7,
R. Sangha
8,
M.F. Savard
6,
S.S. Sridhar
9,
J. Stagg
10,
D.J. Stewart
11 and
S. Verma
6,*
1
Exactis Innovation, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada
2
Segal Cancer Centre, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada
3
William Osler Health System, University of Toronto, Toronto, ON, Canada
4
Division of Hematology Oncology, Cedars–Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA
5
Medical Oncology, BC Cancer–Vancouver Centre, Vancouver, BC, Canada
6
Department of Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada
7
Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
8
Department of Oncology, Cross Cancer Institute, Edmonton, AB, Canada
9
Medical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada
10
Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada
11
Division of Medical Oncology, The Ottawa Hospital, Ottawa, ON, Canada
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(2), 73-79; https://doi.org/10.3747/co.26.4393
Submission received: 8 January 2019 / Revised: 6 February 2019 / Accepted: 5 March 2019 / Published: 1 April 2019

Abstract

Immune checkpoint inhibitors have revolutionized care for many cancer indications, with considerable effort now being focused on increasing the rate, depth, and duration of patient response. One strategy is to combine immune strategies (for example, CTLA-4 and PD-1/L1–directed agents) to harness additive or synergistic efficacy while minimizing toxicity. Despite encouraging results with such combinations in multiple tumour types, numerous clinical challenges remain, including a lack of biomarkers that reliably predict outcome, the emergence of therapeutic resistance, and optimal management of immune-related toxicities. Furthermore, the selection of ideal combinations from the myriad of immune, systemic, and locoregional therapies has yet to be determined. A longitudinal network-based approach could offer advantages in addressing those critical questions, including long-term follow-up of patients beyond individual trials.
Keywords: immuno-oncology; biobanking; molecular profiling; precision oncology; molecular cancer registries; cancer networks immuno-oncology; biobanking; molecular profiling; precision oncology; molecular cancer registries; cancer networks

Share and Cite

MDPI and ACS Style

Higenell, V.; Fajzel, R.; Batist, G.; Cheema, P.K.; McArthur, H.L.; Melosky, B.; Morris, D.; Petrella, T.M.; Sangha, R.; Savard, M.F.; et al. A Network Approach to Developing Immuno-Oncology Combinations in Canada. Curr. Oncol. 2019, 26, 73-79. https://doi.org/10.3747/co.26.4393

AMA Style

Higenell V, Fajzel R, Batist G, Cheema PK, McArthur HL, Melosky B, Morris D, Petrella TM, Sangha R, Savard MF, et al. A Network Approach to Developing Immuno-Oncology Combinations in Canada. Current Oncology. 2019; 26(2):73-79. https://doi.org/10.3747/co.26.4393

Chicago/Turabian Style

Higenell, V., R. Fajzel, G. Batist, P.K. Cheema, H.L. McArthur, B. Melosky, D. Morris, T.M. Petrella, R. Sangha, M.F. Savard, and et al. 2019. "A Network Approach to Developing Immuno-Oncology Combinations in Canada" Current Oncology 26, no. 2: 73-79. https://doi.org/10.3747/co.26.4393

APA Style

Higenell, V., Fajzel, R., Batist, G., Cheema, P. K., McArthur, H. L., Melosky, B., Morris, D., Petrella, T. M., Sangha, R., Savard, M. F., Sridhar, S. S., Stagg, J., Stewart, D. J., & Verma, S. (2019). A Network Approach to Developing Immuno-Oncology Combinations in Canada. Current Oncology, 26(2), 73-79. https://doi.org/10.3747/co.26.4393

Article Metrics

Back to TopTop