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Current Oncology
Volume 24
Issue 6
10.3747/co.24.3738
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report

by
S. H. Yoo
1,
J. Lim
2,
J. M. Byun
3,
J. H. Park
3,
K. H. Kim
3,* and
I. S. Choi
3
1
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
2
Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea
3
Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(6), 547-550; https://doi.org/10.3747/co.24.3738
Submission received: 4 September 2017 / Revised: 3 October 2017 / Accepted: 6 November 2017 / Published: 1 December 2017

Abstract

Chronic myelomonocytic leukemia (CMML) is an indolent disease in the category of myelodysplastic and myeloproliferative neoplasms, which can often evolve into acute leukemic neoplasms. Although cytogenetic abnormalities such as trisomy 8 or absence of chromosome Y are well known, few reports about CMML with trisomy 11 have been published. Here, we report a case of CMML with trisomy 11 as the sole chromosomal abnormality, resulting in a very poor outcome. Based on a bone marrow specimen, CMML-1 with trisomy 11 was diagnosed in a 79-year-old man presenting with anemia and atypical peripheral blood cells. Because of the patient’s age, he was followed without receiving anticancer treatment. Two months after his diagnosis, the patient’s leucocytosis and anemia rapidly worsened, with increasing numbers of immature peripheral cells, which was strongly suggestive of leukemic transformation. Because of acute kidney injury superimposed on chronic kidney disease that led to poor performance status, cytotoxic chemotherapy was not considered feasible, and the patient was transferred to a hospice care facility.
Keywords: myelodysplastic syndrome; chronic myelomonocytic leukemia; trisomy 11; case reports myelodysplastic syndrome; chronic myelomonocytic leukemia; trisomy 11; case reports

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MDPI and ACS Style

Yoo, S.H.; Lim, J.; Byun, J.M.; Park, J.H.; Kim, K.H.; Choi, I.S. Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report. Curr. Oncol. 2017, 24, 547-550. https://doi.org/10.3747/co.24.3738

AMA Style

Yoo SH, Lim J, Byun JM, Park JH, Kim KH, Choi IS. Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report. Current Oncology. 2017; 24(6):547-550. https://doi.org/10.3747/co.24.3738

Chicago/Turabian Style

Yoo, S. H., J. Lim, J. M. Byun, J. H. Park, K. H. Kim, and I. S. Choi. 2017. "Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report" Current Oncology 24, no. 6: 547-550. https://doi.org/10.3747/co.24.3738

APA Style

Yoo, S. H., Lim, J., Byun, J. M., Park, J. H., Kim, K. H., & Choi, I. S. (2017). Adult Chronic Myelomonocytic Leukemia with Trisomy 11: A Case Report. Current Oncology, 24(6), 547-550. https://doi.org/10.3747/co.24.3738

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