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Article

Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer

1
Radiation Oncology, Cancer Centre of Southeastern Ontario, Kingston General Hospital and Queen’s University, Kingston, ON, Canada
2
Cancer Care Ontario, Program in Evidence-Based Care, McMaster University, Hamilton, ON, Canada
3
Radiation Oncology, London Regional Cancer Centre and Western University, London, ON, Canada
4
Radiation Oncology, Durham Regional Cancer Centre, Oshawa, ON, Canada
5
Medical Oncology, Juravinski Cancer Centre, and Department of Oncology, McMaster University, Hamilton, ON, Canada
6
Radiation Oncology, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(1), 44-49; https://doi.org/10.3747/co.24.3358
Received: 7 November 2016 / Revised: 6 December 2016 / Accepted: 5 January 2017 / Published: 1 February 2017
Objectives: For this guideline, we investigated the effectiveness of radiotherapy with curative intent in medically inoperable patients with early-stage non-small-cell lung cancer (nsclc). Methods: The guideline was developed by Cancer Care Ontario’s Program in Evidence-Based Care and by the Lung Cancer Disease Site Group through a systematic review of mainly retrospective studies, expert consensus, and formal internal and external reviews. Recommendations: 1. Stereotactic body radiation therapy (sbrt) with curative intent is an option that should be considered for patients with early-stage, node-negative, medically inoperable nsclc. Qualifying Statements (1) Because of the high dose per fraction, the planning process and treatment delivery for sbrt require the use of advanced technology to maintain an appropriate level of safety. Consistent patient positioning and 4-dimensional analysis of tumour and critical structure motion during simulation and treatment delivery are essential. (2) Preliminary results for proton-beam therapy have been promising, but the technique requires further clinical study. 2. Recommended fractionation schemes for sbrt should result in a biologically effective dose of 100 or greater by the linear quadric model, choosing an α/β value of 10 [bed10(LQ) ≥ 100]. Qualifying Statements (1) Because of the increased risk of treatment-related adverse events associated with centrally located tumours, consideration of tumour size and proximity to critical central structures is required when determining the dose and fractionation. (2) Examples of dose–fractionation schemes used in the included studies have been provided. (3) Based on the current evidence and the opinion of the authors, radiation doses at bed10(LQ) greater than 146 might significantly increase toxicity and should be avoided. (4) Determination of the radiation bed by the linear quadratic model has limitations for the extreme hypofractionated schemes used in sbrt.
Keywords: early-stage disease; inoperable tumours; non-small-cell lung cancer; stereotactic body radiation therapy; stereotactic ablative radiation therapy; clinical practice guidelines early-stage disease; inoperable tumours; non-small-cell lung cancer; stereotactic body radiation therapy; stereotactic ablative radiation therapy; clinical practice guidelines
MDPI and ACS Style

Falkson, C.B.; Vella, E.T.; Yu, E.; El-Mallah, M.; Mackenzie, R.; Ellis, P.M.; Ung, Y.C. Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer. Curr. Oncol. 2017, 24, 44-49. https://doi.org/10.3747/co.24.3358

AMA Style

Falkson CB, Vella ET, Yu E, El-Mallah M, Mackenzie R, Ellis PM, Ung YC. Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer. Current Oncology. 2017; 24(1):44-49. https://doi.org/10.3747/co.24.3358

Chicago/Turabian Style

Falkson, C.B.; Vella, E.T.; Yu, E.; El-Mallah, M.; Mackenzie, R.; Ellis, P.M.; Ung, Y.C. 2017. "Guideline for Radiotherapy with Curative Intent in Patients with Early-Stage Medically Inoperable Non-Small-Cell Lung Cancer" Curr. Oncol. 24, no. 1: 44-49. https://doi.org/10.3747/co.24.3358

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