Next Article in Journal
A Canadian Perspective on the Subcutaneous Administration of Rituximab in Non-Hodgkin Lymphoma
Previous Article in Journal
The Hospital at Home Program: No Place Like Home
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
Open AccessArticle

Does Adjuvant Radiation Therapy Benefit Women with Small Mammography-Detected Breast Cancers?

by 1,*, 2, 3,4, 5 and 4,5
1
Department of Medicine, University of Toronto, Toronto, ON, Canada
2
McMaster University, Hamilton, ON, Canada
3
Department of Medicine, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada
4
Dal la Lana School of Public Health, University of Toronto, Toronto, ON, Canada
5
Women’s College Research Institute, Women’s College Hospital, Toronto, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2017, 24(1), 28-32; https://doi.org/10.3747/co.24.3089
Received: 16 October 2016 / Revised: 11 November 2016 / Accepted: 12 December 2016 / Published: 1 February 2017
Background: Women with small nonpalpable breast tumours have an excellent prognosis. The benefit of radiotherapy in this group of low-risk women is unknown. Methods: A cohort of 1595 women with stages i–iii invasive breast cancer treated with breast-conserving surgery were followed for local recurrence. Using t-tests, baseline demographic data and tumour characteristics were compared for the women who had palpable (n = 1023) and mammography-detected (n = 572) breast cancers. The 15-year actuarial risk of local recurrence was estimated using a Kaplan–Meier method, stratified for adjuvant radiation therapy (yes or no), tumour palpability (palpable or not), and tumour size (≤1 cm or >1 cm). Hazard ratios (hrs) and 95% confidence intervals (95% cis) were calculated using a multivariate Cox regression model. Results were considered statistically significant if 2-tailed p values were less than 0.05. Results: Among women with a nonpalpable tumour, the 15-year actuarial rates of local recurrence were, respectively, 13.9% and 18.3% for those treated and not treated with adjuvant radiation therapy (hr: 0.65; 95%ci: 0.40 to 1.06; p = 0.08). Among women with small nonpalpable breast cancers (≤1.0 cm), the rates were 14.6% and 13.4% respectively (p = 0.67). The absolute reduction in 15-year local recurrence was 11.0% for women with palpable tumours. Conclusions: Our results suggest that women with small (<1 cm) screen-detected nonpalpable breast cancers likely derive little benefit from adjuvant radiotherapy; however, an adequately powered randomized trial would be required to make definitive conclusions.
Keywords: breast cancer; radiation therapy; palpable breast tumours breast cancer; radiation therapy; palpable breast tumours
MDPI and ACS Style

Jerzak, K.; Dudalski, N.; Pritchard, K.; Sun, P.; Narod, S.A. Does Adjuvant Radiation Therapy Benefit Women with Small Mammography-Detected Breast Cancers? Curr. Oncol. 2017, 24, 28-32. https://doi.org/10.3747/co.24.3089

AMA Style

Jerzak K, Dudalski N, Pritchard K, Sun P, Narod SA. Does Adjuvant Radiation Therapy Benefit Women with Small Mammography-Detected Breast Cancers? Current Oncology. 2017; 24(1):28-32. https://doi.org/10.3747/co.24.3089

Chicago/Turabian Style

Jerzak, K.; Dudalski, N.; Pritchard, K.; Sun, P.; Narod, S.A. 2017. "Does Adjuvant Radiation Therapy Benefit Women with Small Mammography-Detected Breast Cancers?" Curr. Oncol. 24, no. 1: 28-32. https://doi.org/10.3747/co.24.3089

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop