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Current Oncology
Volume 23
Issue 4
10.3747/co.23.3082
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

High-Grade Glioma Management and Response Assessment—Recent Advances and Current Challenges

by
M.N. Khan
1,*,
A.M. Sharma
1,2,
M. Pitz
3,4,
S.K. Loewen
1,2,
H. Quon
1,2,
A. Poulin
1,5 and
M. Essig
1
1
Department of Radiology, University of Manitoba, Winnipeg, MB, Canada
2
Department of Radiation Oncology, CancerCare Manitoba, Winnipeg, MB, Canada
3
Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
4
Department of Haematology and Medical Oncology, University of Manitoba, Winnipeg, MB, Canada
5
Department of Radiology, Laval University, Quebec City, QC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2016, 23(4), 383-391; https://doi.org/10.3747/co.23.3082
Submission received: 9 May 2016 / Revised: 8 June 2016 / Accepted: 7 July 2016 / Published: 1 August 2016

Abstract

The management of high-grade gliomas (hggs) is complex and ever-evolving. The standard of care for the treatment of hggs consists of surgery, chemotherapy, and radiotherapy. However, treatment options are influenced by multiple factors such as patient age and performance status, extent of tumour resection, biomarker profile, and tumour histology and grade. Follow-up cranial magnetic resonance imaging (mri) to differentiate treatment response from treatment effect can be challenging and affects clinical decision-making. An assortment of advanced radiologic techniques—including perfusion imaging with dynamic susceptibility contrast mri, dynamic contrast-enhanced mri, diffusion-weighted imaging, proton spectroscopy, mri subtraction imaging, and amino acid radiotracer imaging—can now incorporate novel physiologic data, providing new methods to help characterize tumour progression, pseudoprogression, and pseudoresponse. In the present review, we provide an overview of current treatment options for hgg and summarize recent advances and challenges in imaging technology.
Keywords: gliomas; pseudoprogression; pseudoresponse; perfusion; diffusion gliomas; pseudoprogression; pseudoresponse; perfusion; diffusion

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MDPI and ACS Style

Khan, M.N.; Sharma, A.M.; Pitz, M.; Loewen, S.K.; Quon, H.; Poulin, A.; Essig, M. High-Grade Glioma Management and Response Assessment—Recent Advances and Current Challenges. Curr. Oncol. 2016, 23, 383-391. https://doi.org/10.3747/co.23.3082

AMA Style

Khan MN, Sharma AM, Pitz M, Loewen SK, Quon H, Poulin A, Essig M. High-Grade Glioma Management and Response Assessment—Recent Advances and Current Challenges. Current Oncology. 2016; 23(4):383-391. https://doi.org/10.3747/co.23.3082

Chicago/Turabian Style

Khan, M.N., A.M. Sharma, M. Pitz, S.K. Loewen, H. Quon, A. Poulin, and M. Essig. 2016. "High-Grade Glioma Management and Response Assessment—Recent Advances and Current Challenges" Current Oncology 23, no. 4: 383-391. https://doi.org/10.3747/co.23.3082

APA Style

Khan, M. N., Sharma, A. M., Pitz, M., Loewen, S. K., Quon, H., Poulin, A., & Essig, M. (2016). High-Grade Glioma Management and Response Assessment—Recent Advances and Current Challenges. Current Oncology, 23(4), 383-391. https://doi.org/10.3747/co.23.3082

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