Next Article in Journal
Urologist Referral Delay and Its Impact on Survival after Radical Cystectomy for Bladder Cancer
Previous Article in Journal
Publishing Clinical Research: Ten Pearls for Oncology Trainees and Junior Oncologists
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 22
Issue 1
10.3747/co.22.2150
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Distribution and Clinical Significance of Tumour-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis in China

by
S.J. Chen
1,2,
Q.B. Zhang
3,
L.J. Zeng
4,
G.D. Lian
1,2,
J.J. Li
1,2,
C.C. Qian
1,2,
Y.Z. Chen
1,2,
Y.T. Chen
1,2 and
K.H. Huang
1,2,*
1
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
2
Department of Gastroenterology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China
3
Department of Gastroenterology, Lihuili Hospital of Ningbo Medical Center, Ningbo, China
4
Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2015, 22(1), 11-19; https://doi.org/10.3747/co.22.2150
Submission received: 4 November 2014 / Revised: 2 December 2014 / Accepted: 8 January 2015 / Published: 3 February 2015

Abstract

Background: We aimed to characterize the localization and prognostic significance of tumour-associated macrophages (tams) in pancreatic ductal adenocarcinoma (pdac). Methods: Tumour specimens from 70 patients with pdac and inflammatory specimens from 13 patients with chronic pancreatitis were collected and analyzed for tam and M2 macrophage counts by immunohistochemistry. Correlations between tam distributions and clinicopathologic features were determined. Results: Immunohistochemical analysis showed that tam and M2 macrophage counts were higher in tissues from pdac than from chronic pancreatitis. The tams and M2 macrophages both infiltrated more into peritumour. Both macrophage types were positively associated with lymph node metastasis (p = 0.041 for tams in peritumour, p = 0.013 for M2 macrophages in introtumour, p = 0.006 for M2 macrophage in peritumour). In addition, abdominal pain was significantly more frequent in pdac patients with a greater tams count. The survival rate was much lower in patients having high infiltration by M2 macrophages than in those having low infiltration. Conclusions: The tam count might be associated with neural invasion in pdac, and M2 macrophages might play an important role in lymph node metastasis. Higher counts of either macrophage type were associated with increased risk of lymph node metastasis, and the M2 macrophage count could potentially be a marker for evaluating prognosis.
Keywords: pancreatic cancer; tumour-associated macrophages; lymph node metastasis; neural invasion pancreatic cancer; tumour-associated macrophages; lymph node metastasis; neural invasion

Share and Cite

MDPI and ACS Style

Chen, S.J.; Zhang, Q.B.; Zeng, L.J.; Lian, G.D.; Li, J.J.; Qian, C.C.; Chen, Y.Z.; Chen, Y.T.; Huang, K.H. Distribution and Clinical Significance of Tumour-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis in China. Curr. Oncol. 2015, 22, 11-19. https://doi.org/10.3747/co.22.2150

AMA Style

Chen SJ, Zhang QB, Zeng LJ, Lian GD, Li JJ, Qian CC, Chen YZ, Chen YT, Huang KH. Distribution and Clinical Significance of Tumour-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis in China. Current Oncology. 2015; 22(1):11-19. https://doi.org/10.3747/co.22.2150

Chicago/Turabian Style

Chen, S.J., Q.B. Zhang, L.J. Zeng, G.D. Lian, J.J. Li, C.C. Qian, Y.Z. Chen, Y.T. Chen, and K.H. Huang. 2015. "Distribution and Clinical Significance of Tumour-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis in China" Current Oncology 22, no. 1: 11-19. https://doi.org/10.3747/co.22.2150

APA Style

Chen, S. J., Zhang, Q. B., Zeng, L. J., Lian, G. D., Li, J. J., Qian, C. C., Chen, Y. Z., Chen, Y. T., & Huang, K. H. (2015). Distribution and Clinical Significance of Tumour-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis in China. Current Oncology, 22(1), 11-19. https://doi.org/10.3747/co.22.2150

Article Metrics

Back to TopTop