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Current Oncology
Volume 21
Issue 6
10.3747/co.21.2147
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Successful Use of Metronomic Vinblastine and Fluorothymidine pet Imaging for the Management of Intramedullary Spinal Cord Anaplastic Oligoastrocytoma in a Child

by
R. Demlova
1,2,
K. Melicharkova
3,
Z. Rehak
2,4,
L. Kren
5,
H. Oslejskova
6 and
J. Sterba
2,3,*
1
Department of Pharmacology, Masaryk University School of Medicine, Brno, Czech Republic
2
Regional Center for Applied Molecular Oncology, Brno, Czech Republic
3
Department of Pediatric Oncology, University Hospital Brno, Brno, Czech Republic
4
Department of Nuclear Medicine, Masaryk Memorial Cancer Institute, Brno, Czech Republic
5
Department of Pathology, University Hospital Brno, Brno, Czech Republic
6
Department of Pediatric Neurology, University Hospital Brno, Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2014, 21(6), 790-793; https://doi.org/10.3747/co.21.2147
Submission received: 3 September 2014 / Revised: 8 October 2014 / Accepted: 11 November 2014 / Published: 1 December 2014

Abstract

Background: Children with high-grade glioma still have a poor prognosis despite the use of multimodal therapy including surgery, radiotherapy, and chemotherapy. New therapeutic strategies and methods evaluating such therapies are needed. Observation: Here we describe a child with anaplastic oligodendroglioma of the spinal cord who was unable to tolerate standard chemoradiotherapy and who had still-vital residual tumour during therapy. A good response was obtained with low-dose metronomic treatment containing vinblastine. The treatment was guided according to gradual response assessed using various positron-emission tomography tracers. Conclusions: Metronomic treatment guided by positron-emission tomography could be a reasonable option in some high-risk pediatric tumours.
Keywords: metronomic chemotherapy; pet imaging; biomarkers; vinblastine; pediatric glioma metronomic chemotherapy; pet imaging; biomarkers; vinblastine; pediatric glioma

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MDPI and ACS Style

Demlova, R.; Melicharkova, K.; Rehak, Z.; Kren, L.; Oslejskova, H.; Sterba, J. Successful Use of Metronomic Vinblastine and Fluorothymidine pet Imaging for the Management of Intramedullary Spinal Cord Anaplastic Oligoastrocytoma in a Child. Curr. Oncol. 2014, 21, 790-793. https://doi.org/10.3747/co.21.2147

AMA Style

Demlova R, Melicharkova K, Rehak Z, Kren L, Oslejskova H, Sterba J. Successful Use of Metronomic Vinblastine and Fluorothymidine pet Imaging for the Management of Intramedullary Spinal Cord Anaplastic Oligoastrocytoma in a Child. Current Oncology. 2014; 21(6):790-793. https://doi.org/10.3747/co.21.2147

Chicago/Turabian Style

Demlova, R., K. Melicharkova, Z. Rehak, L. Kren, H. Oslejskova, and J. Sterba. 2014. "Successful Use of Metronomic Vinblastine and Fluorothymidine pet Imaging for the Management of Intramedullary Spinal Cord Anaplastic Oligoastrocytoma in a Child" Current Oncology 21, no. 6: 790-793. https://doi.org/10.3747/co.21.2147

APA Style

Demlova, R., Melicharkova, K., Rehak, Z., Kren, L., Oslejskova, H., & Sterba, J. (2014). Successful Use of Metronomic Vinblastine and Fluorothymidine pet Imaging for the Management of Intramedullary Spinal Cord Anaplastic Oligoastrocytoma in a Child. Current Oncology, 21(6), 790-793. https://doi.org/10.3747/co.21.2147

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