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Current Oncology
Volume 21
Issue 3
10.3747/co.21.1777
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Compared with Concurrent Chemoradiotherapy Alone for the Treatment of Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Controlled Study

by
Z. Liang
,
X. Zhu
*,
L. Li
,
S. Qu
,
X. Liang
,
Z. Liang
,
F. Su
,
Y. Li
and
W. Zhao
Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, China
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2014, 21(3), 408-417; https://doi.org/10.3747/co.21.1777
Submission received: 2 March 2014 / Revised: 3 April 2014 / Accepted: 4 May 2014 / Published: 1 June 2014

Abstract

Objective: We evaluated the survival benefit of providing concurrent chemoradiotherapy (ccrt) plus adjuvant chemotherapy compared with ccrt alone to patients with locally advanced nasopharyngeal carcinoma. Methods: This retrospective study included 130 patients with nasopharyngeal carcinoma treated with ccrt plus adjuvant chemotherapy from June 2005 to December 2010. Another 130 patients treated with ccrt alone during the same period were matched on age, sex, World Health Organization histology, T stage, N stage, and technology used for radiotherapy. The endpoints included overall survival, locoregional failure-free survival, distant metastasis failure-free survival, and failure-free survival. Results: At a mean follow-up of 42.1 months (range: 8–85 months), the observed hazard ratios for the group receiving ccrt plus adjuvant chemotherapy compared with the group receiving ccrt alone were: for overall survival, 0.77 [95% confidence interval (ci): 0.37 to 1.57]; for locoregional failure-free survival, 1.00 (95% ci: 0.37 to 2.71); for distant metastasis failure-free survival, 1.15 (95% ci: 0.56 to 2.37); and for failure-free survival, 1.26 (95% ci: 0.69 to 2.28). There were no significant differences in survival between the groups. After stratification by disease stage, ccrt plus adjuvant chemotherapy provided a borderline significant benefit for patients with N2–3 disease (hazard ratio: 0.35; 95% ci: 0.11 to 1.06; p = 0.052). Multivariate analyses indicated that only tumour stage was a prognostic factor for overall survival. Conclusions: Patients with locally advanced nasopharyngeal carcinoma received no significant survival benefit from the addition of adjuvant chemotherapy to ccrt. However, patients with N2–3 disease might benefit from the addition of adjuvant chemotherapy to ccrt.
Keywords: nasopharyngeal carcinoma; concurrent chemoradiotherapy; adjuvant chemotherapy nasopharyngeal carcinoma; concurrent chemoradiotherapy; adjuvant chemotherapy

Share and Cite

MDPI and ACS Style

Liang, Z.; Zhu, X.; Li, L.; Qu, S.; Liang, X.; Liang, Z.; Su, F.; Li, Y.; Zhao, W. Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Compared with Concurrent Chemoradiotherapy Alone for the Treatment of Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Controlled Study. Curr. Oncol. 2014, 21, 408-417. https://doi.org/10.3747/co.21.1777

AMA Style

Liang Z, Zhu X, Li L, Qu S, Liang X, Liang Z, Su F, Li Y, Zhao W. Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Compared with Concurrent Chemoradiotherapy Alone for the Treatment of Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Controlled Study. Current Oncology. 2014; 21(3):408-417. https://doi.org/10.3747/co.21.1777

Chicago/Turabian Style

Liang, Z., X. Zhu, L. Li, S. Qu, X. Liang, Z. Liang, F. Su, Y. Li, and W. Zhao. 2014. "Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Compared with Concurrent Chemoradiotherapy Alone for the Treatment of Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Controlled Study" Current Oncology 21, no. 3: 408-417. https://doi.org/10.3747/co.21.1777

APA Style

Liang, Z., Zhu, X., Li, L., Qu, S., Liang, X., Liang, Z., Su, F., Li, Y., & Zhao, W. (2014). Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Compared with Concurrent Chemoradiotherapy Alone for the Treatment of Locally Advanced Nasopharyngeal Carcinoma: A Retrospective Controlled Study. Current Oncology, 21(3), 408-417. https://doi.org/10.3747/co.21.1777

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