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Current Oncology
Volume 21
Issue 2
10.3747/co.21.1656
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

A Prior Diagnosis of Breast Cancer is a Risk Factor for Breast Cancer in Brca1 and Brca2 Carriers

by
S.A. Narod
1,*,
N. Tung
2,
J. Lubinski
3,
T. Huzarski
3,
M. Robson
4,
H.T. Lynch
5,
S.L. Neuhausen
6,
P. Ghadirian
7,
C. Kim–Sing
8,
P. Sun
1,
W.D. Foulkes
9 and
the Hereditary Breast Cancer Clinical Study Group
1
Women’s College Research Institute, University of Toronto, Toronto, ON, Canada
2
Beth Israel Deaconness Hospital, Boston, MA, USA
3
Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland
4
Clinical Genetics Service, Memorial Sloan–Kettering Cancer Center, New York City, NY, USA
5
‖Department of Preventive Medicine, Creighton University, Omaha, NE, USA
6
Beckman Research Institute of the City of Hope, Duarte, CA, USA
7
Epidemiology Research Unit, CHUM–Hôtel-Dieu, Montreal, QC, Canada
8
BC Cancer Agency, Vancouver, BC, Canada
9
Departments of Medical Genetics and Oncology, McGill University, Montreal, QC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2014, 21(2), 64-68; https://doi.org/10.3747/co.21.1656
Submission received: 2 January 2014 / Revised: 3 February 2014 / Accepted: 4 March 2014 / Published: 1 April 2014

Abstract

Background: The risk of breast cancer in carriers of BRCA1 and BRCA2 mutations is influenced by factors other than the genetic mutation itself. Modifying factors include a woman’s reproductive history and family history of cancer. Risk factors are more likely to be present in women with breast cancer than in women without breast cancer, and therefore the risk of cancer in the two breasts should not be independent. It is not clear to what extent modifying factors influence the risk of a first primary or a contralateral breast cancer in BRCA carriers. Methods: We conducted a matched case–control study of breast cancer among 3920 BRCA1 or BRCA2 mutation carriers. We asked whether a past history of breast cancer in the contralateral breast was a risk factor for breast cancer. Results: After adjustment for age, country of residence, and cancer treatment, a previous cancer of the right breast was found to be a significant risk factor for cancer of the left breast among BRCA1 or BRCA2 carriers (relative risk: 2.1; 95% confidence interval: 1.4 to 3.0; p < 0.0001). Conclusions: In a woman with a BRCA1 or BRCA2 mutation who is diagnosed with breast cancer, the risk of cancer in the contralateral breast depends on the first diagnosis. That observation supports the hypothesis that there are important genetic or non-genetic modifiers of cancer risk in BRCA carriers. Discovering risk modifiers might lead to greater personalization of risk assessment and management recommendations for BRCA-positive patients.
Keywords: BRCA1; BRCA2; contralateral breast cancer BRCA1; BRCA2; contralateral breast cancer

Share and Cite

MDPI and ACS Style

Narod, S.A.; Tung, N.; Lubinski, J.; Huzarski, T.; Robson, M.; Lynch, H.T.; Neuhausen, S.L.; Ghadirian, P.; Kim–Sing, C.; Sun, P.; et al. A Prior Diagnosis of Breast Cancer is a Risk Factor for Breast Cancer in Brca1 and Brca2 Carriers. Curr. Oncol. 2014, 21, 64-68. https://doi.org/10.3747/co.21.1656

AMA Style

Narod SA, Tung N, Lubinski J, Huzarski T, Robson M, Lynch HT, Neuhausen SL, Ghadirian P, Kim–Sing C, Sun P, et al. A Prior Diagnosis of Breast Cancer is a Risk Factor for Breast Cancer in Brca1 and Brca2 Carriers. Current Oncology. 2014; 21(2):64-68. https://doi.org/10.3747/co.21.1656

Chicago/Turabian Style

Narod, S.A., N. Tung, J. Lubinski, T. Huzarski, M. Robson, H.T. Lynch, S.L. Neuhausen, P. Ghadirian, C. Kim–Sing, P. Sun, and et al. 2014. "A Prior Diagnosis of Breast Cancer is a Risk Factor for Breast Cancer in Brca1 and Brca2 Carriers" Current Oncology 21, no. 2: 64-68. https://doi.org/10.3747/co.21.1656

APA Style

Narod, S. A., Tung, N., Lubinski, J., Huzarski, T., Robson, M., Lynch, H. T., Neuhausen, S. L., Ghadirian, P., Kim–Sing, C., Sun, P., Foulkes, W. D., & , the Hereditary Breast Cancer Clinical Study Group. (2014). A Prior Diagnosis of Breast Cancer is a Risk Factor for Breast Cancer in Brca1 and Brca2 Carriers. Current Oncology, 21(2), 64-68. https://doi.org/10.3747/co.21.1656

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