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Current Oncology
Volume 18
Issue 5
10.3747/co.v18i5.789
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

Durable Remission of Inoperable Liver Metastasis from Rectal Cancer after Hepatic Arterial Infusion of Oxaliplatin and 5-Fluorouracil in Combination with Intravenous Cetuximab

by
K. Van Bael
1,*,
M. Aerts
2,
M. de Ridder
3,
J. de Gréve
2,
G. Delvaux
1 and
B. Neyns
2
1
Department of Surgical Oncology, Oncologisch Centrum UZ Brussel, Brussels, Belgium
2
Department of Medical Oncology, Oncologisch Centrum UZ Brussel, B-1090 Brussels, Belgium
3
Department of Radiotherapy, Oncologisch Centrum UZ Brussel, Brussels, Belgium
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2011, 18(5), 256-259; https://doi.org/10.3747/co.v18i5.789
Submission received: 1 July 2011 / Revised: 2 August 2011 / Accepted: 3 September 2011 / Published: 1 October 2011

Abstract

At diagnosis of a cT3N0M1 adenocarcinoma of the rectum with synchronous inoperable liver metastases, a 59-year-old man was treated with preoperative radiotherapy (5×5 Gy), followed by laparoscopy-assisted anterior resection of the rectum with total mesorectal excision. At the first postoperative evaluation, a new lung metastasis was detected. First-line chemotherapy with folfiri (5-fluorouracil, irinotecan, leucovorin) resulted in transient stabilization of the metastatic liver disease. At progression, oxaliplatin and 5-fluorouracil–folinic acid were administered by intrahepatic arterial infusion, in combination with intravenous cetuximab. A partial radiologic response was obtained, with complete metabolic response on fluorodeoxyglucose positron-emission tomography, and normalization of carcinoembryonic antigen values. The solitary lung metastasis was sequentially treated with radiotherapy and resection. Five years after the initial diagnosis, this patient remains free from progression, with residual cystic remnants of the liver metastases visible on conventional computed tomography imaging, but not enhancing with fluorodeoxyglucose positron-emission tomography.
Keywords: Hepatic arterial infusion; colorectal; liver metastases; cetuximab; oxaliplatin; remission Hepatic arterial infusion; colorectal; liver metastases; cetuximab; oxaliplatin; remission

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MDPI and ACS Style

Van Bael, K.; Aerts, M.; de Ridder, M.; de Gréve, J.; Delvaux, G.; Neyns, B. Durable Remission of Inoperable Liver Metastasis from Rectal Cancer after Hepatic Arterial Infusion of Oxaliplatin and 5-Fluorouracil in Combination with Intravenous Cetuximab. Curr. Oncol. 2011, 18, 256-259. https://doi.org/10.3747/co.v18i5.789

AMA Style

Van Bael K, Aerts M, de Ridder M, de Gréve J, Delvaux G, Neyns B. Durable Remission of Inoperable Liver Metastasis from Rectal Cancer after Hepatic Arterial Infusion of Oxaliplatin and 5-Fluorouracil in Combination with Intravenous Cetuximab. Current Oncology. 2011; 18(5):256-259. https://doi.org/10.3747/co.v18i5.789

Chicago/Turabian Style

Van Bael, K., M. Aerts, M. de Ridder, J. de Gréve, G. Delvaux, and B. Neyns. 2011. "Durable Remission of Inoperable Liver Metastasis from Rectal Cancer after Hepatic Arterial Infusion of Oxaliplatin and 5-Fluorouracil in Combination with Intravenous Cetuximab" Current Oncology 18, no. 5: 256-259. https://doi.org/10.3747/co.v18i5.789

APA Style

Van Bael, K., Aerts, M., de Ridder, M., de Gréve, J., Delvaux, G., & Neyns, B. (2011). Durable Remission of Inoperable Liver Metastasis from Rectal Cancer after Hepatic Arterial Infusion of Oxaliplatin and 5-Fluorouracil in Combination with Intravenous Cetuximab. Current Oncology, 18(5), 256-259. https://doi.org/10.3747/co.v18i5.789

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