Next Article in Journal
First- and Second-Line Therapy for Metastatic Urothelial Carcinoma of the Bladder
Previous Article in Journal
A Comparative Analysis of Monthly Out-of-Pocket Costs for Patients with Breast Cancer as Compared with Other Common Cancers in Ontario, Canada
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Current Oncology
Volume 18
Issue 1
10.3747/co.v18i1.675
curroncol-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium

by
Ute Bartels
1,*,
S. Baruchel
1,
A. S. Carret
2,
B. Crooks
3,
J. Hukin
4,
D. Johnston
5,
M. Silva
6,
D. Strother
7,
B. Wilson
8,
S. Zelcer
9,
D. Eisenstat
10,
L. Sung
1 and
E. Bouffet
1
1
Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
2
Montreal Children’s Hospital, Montreal, QC, Canada
3
IWK Health Centre, Halifax, NS, Canada
4
British Columbia’s Children’s Hospital, Vancouver, BC, Canada
5
Children’s Hospital of Easter n Ontario, Ottawa, ON, Canada
6
Kingston General Hospital, Kingston, ON, Canada
7
Alberta Hospital, University of Calgary, Calgary, AB, Canada
8
Stollery Children’s Hospital, Edmonton, AB, Canada
9
Children’s Hospital of Western Ontario, London, ON, Canada
10
CancerCare Manitoba, Winnipeg, MB, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2011, 18(1), 675; https://doi.org/10.3747/co.v18i1.675
Submission received: 9 November 2010 / Revised: 8 December 2010 / Accepted: 5 January 2011 / Published: 1 February 2011

Abstract

Objective: To describe the use of temozolomide (TMZ) in Canadian children treated for brain tumours and to evaluate survival and predictors of survival for children treated with this agent. Methods: A survey was conducted within the Canadian Paediatric Brain Tumour Consortium (CPBTC), a group of tertiary care centres in pediatric neurooncology (n = 16) in Canada that are involved in the treatment of children with central nervous system tumours. Results: In 10 of the 16 participating pediatric oncology centres of the CPBTC, 137 children with brain tumours were treated with TMZ between January 2000 and March 2006. Although 33% of the children were enrolled into a clinical trial, 67% were treated outside open studies. Most patients (72%) received TMZ treatment on recurrence of their brain tumour (first or subsequent). The most commonly administered regimen was single-agent TMZ 150–200 mg/ m2 administered on 5 consecutive days every 28 days. The median duration of TMZ treatment was 141 days (range: 4–1102 days). Response data were provided for 127 of the 137 patients, of whom 6 showed a complete response. Sixteen patients experienced a minor or partial response, 53 had stable disease, and 52 had progressive disease. Of 32 patients alive at last follow-up, 19 had a diagnosis of low-grade glioma.
Keywords: temozolomide; children; pediatric; cns; brain tumour temozolomide; children; pediatric; cns; brain tumour

Share and Cite

MDPI and ACS Style

Bartels, U.; Baruchel, S.; Carret, A.S.; Crooks, B.; Hukin, J.; Johnston, D.; Silva, M.; Strother, D.; Wilson, B.; Zelcer, S.; et al. The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium. Curr. Oncol. 2011, 18, 675. https://doi.org/10.3747/co.v18i1.675

AMA Style

Bartels U, Baruchel S, Carret AS, Crooks B, Hukin J, Johnston D, Silva M, Strother D, Wilson B, Zelcer S, et al. The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium. Current Oncology. 2011; 18(1):675. https://doi.org/10.3747/co.v18i1.675

Chicago/Turabian Style

Bartels, Ute, S. Baruchel, A. S. Carret, B. Crooks, J. Hukin, D. Johnston, M. Silva, D. Strother, B. Wilson, S. Zelcer, and et al. 2011. "The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium" Current Oncology 18, no. 1: 675. https://doi.org/10.3747/co.v18i1.675

APA Style

Bartels, U., Baruchel, S., Carret, A. S., Crooks, B., Hukin, J., Johnston, D., Silva, M., Strother, D., Wilson, B., Zelcer, S., Eisenstat, D., Sung, L., & Bouffet, E. (2011). The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium. Current Oncology, 18(1), 675. https://doi.org/10.3747/co.v18i1.675

Article Metrics

Back to TopTop