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Current Oncology
Volume 17
Issue 6
10.3747/co.v17i6.578
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II Trial

by
Hazem Assi
1,*,
G. Missenard
2,
P. Terrier
3,
C. Le Pechoux
3,
S. Bonvalot
2,
D. Vanel
4,
J.B. Meric
5,
T. Tursz
5 and
A. LeCesne
5
1
The Moncton Hospital, Oncology Division, 135 MacBeath Avenue, Moncton, NB E1C 6Z8, Canada
2
Department of Surgery, Institut Gustave-Roussy, Villejuif, France
3
Department of Pathology, Institut Gustave-Roussy, Villejuif, France
4
Department of Radiology, Institut Gustave-Roussy, Villejuif, France
5
Department of Medicine, Institut Gustave-Roussy, Villejuif, France
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2010, 17(6), 23-31; https://doi.org/10.3747/co.v17i6.578
Submission received: 11 August 2010 / Revised: 7 September 2010 / Accepted: 12 October 2010 / Published: 1 November 2010

Abstract

Purpose: To improve outcomes in localized osteosarcoma and to reduce the duration of preoperative chemotherapy, we conducted a phase ii trial assessing the efficacy of an intensive protracted regimen without methotrexate (API-AI regimen) in adolescent and adult patients with newly diagnosed disease. Patients and Methods: Induction chemotherapy consisted of 2 cycles (4 courses) of doxorubicin 60 mg/m2 (days 1 and 15), cisplatin 100 mg/m2 (day 1), and ifosfamide 5 g/m2 (days 2 and 15). The primary endpoint was good histologic response [GHR (≤5% identifiable tumour cells)]. Results: From March 1993 to March 2000, 32 patients [median age: 21 years (range: 15–49 years)] were administered 126 induction courses. The median time between chemotherapy courses was 15 days (range: 12–32 days). All but 3 patients underwent conservative surgery. Toxicity was mainly hematologic, with febrile neutropenia occurring in 35% of patients and grades 3–4 thrombocytopenia in 35%. The GHR rate was 47%. The median follow-up was 64 months (range: 30–115 months). The 5-year event-free and overall survivals were 65% [95% confidence interval (CI): 48–79%] and 69% (95% CI: 50–83%) respectively. Two secondary hematologic malignancies occurred: 1 acute myelocytic leukemia (M5) in a poor responder with concomitant relapse, and 1 myelodysplastic syndrome in a patient achieving GHR. Conclusions: Despite hematologic toxicity, the results observed with the API-AI regimen compare favourably with those observed during previous induction chemotherapy containing methotrexate in adult patients and the pediatric population treated at our institution. These promising results have to be validated by an ongoing national multicentre trial coordinated by the French Sarcoma Group.
Keywords: induction chemotherapy; osteosarcoma induction chemotherapy; osteosarcoma

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MDPI and ACS Style

Assi, H.; Missenard, G.; Terrier, P.; Le Pechoux, C.; Bonvalot, S.; Vanel, D.; Meric, J.B.; Tursz, T.; LeCesne, A. Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II Trial. Curr. Oncol. 2010, 17, 23-31. https://doi.org/10.3747/co.v17i6.578

AMA Style

Assi H, Missenard G, Terrier P, Le Pechoux C, Bonvalot S, Vanel D, Meric JB, Tursz T, LeCesne A. Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II Trial. Current Oncology. 2010; 17(6):23-31. https://doi.org/10.3747/co.v17i6.578

Chicago/Turabian Style

Assi, Hazem, G. Missenard, P. Terrier, C. Le Pechoux, S. Bonvalot, D. Vanel, J.B. Meric, T. Tursz, and A. LeCesne. 2010. "Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II Trial" Current Oncology 17, no. 6: 23-31. https://doi.org/10.3747/co.v17i6.578

APA Style

Assi, H., Missenard, G., Terrier, P., Le Pechoux, C., Bonvalot, S., Vanel, D., Meric, J. B., Tursz, T., & LeCesne, A. (2010). Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II Trial. Current Oncology, 17(6), 23-31. https://doi.org/10.3747/co.v17i6.578

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