Next Article in Journal
Clinical Implications of Next-Generation Sequencing for Cancer Medicine
Previous Article in Journal
Hypofractionated Radiotherapy and Adjuvant Chemotherapy Do Not Increase Radiation-Induced Dermatitis in Breast Cancer Patients
 
 
Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer—A Critical Review

Department of Oncology, Division of Radiation Oncology, McGill University Health Centre, Montreal, QC H4X 2C5, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2010, 17(5), 28-38; https://doi.org/10.3747/co.v17i5.632
Submission received: 2 July 2010 / Revised: 3 August 2010 / Accepted: 5 September 2010 / Published: 1 October 2010

Abstract

Interest has been increasing in the use of androgen deprivation therapy (adt) combined with radiation therapy (rt) in the management of localized prostate cancer. Preclinical studies have provided some rationale for the use of this combination. In patients with high-risk disease, the benefit of a combined approach, with the addition of adjuvant hormonal therapy, is supported by results of randomized trials. In contrast, for patients with low-risk disease, there is no obvious therapeutic advantage except for cytoreduction. The usefulness of short-term hormonal therapy in association with rt for intermediate-risk patients is still debatable, particularly in the context of dose-escalated rt. The optimal timing and duration of adt, in the neoadjuvant and adjuvant settings alike, are still under investigation. In view of the potential side effects with adt, further studies are being performed to better identify subsets of patients who will definitely benefit from this therapy in combination with rt.
Keywords: prostate cancer; radiotherapy; hormonal therapy; androgen deprivation therapy; combined treatment prostate cancer; radiotherapy; hormonal therapy; androgen deprivation therapy; combined treatment

Share and Cite

MDPI and ACS Style

Dal Pra, A.; Cury, F.L.; Souhami, L. Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer—A Critical Review. Curr. Oncol. 2010, 17, 28-38. https://doi.org/10.3747/co.v17i5.632

AMA Style

Dal Pra A, Cury FL, Souhami L. Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer—A Critical Review. Current Oncology. 2010; 17(5):28-38. https://doi.org/10.3747/co.v17i5.632

Chicago/Turabian Style

Dal Pra, A., F. L. Cury, and L. Souhami. 2010. "Combining Radiation Therapy and Androgen Deprivation for Localized Prostate Cancer—A Critical Review" Current Oncology 17, no. 5: 28-38. https://doi.org/10.3747/co.v17i5.632

Article Metrics

Back to TopTop