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Current Oncology
Volume 17
Issue 5
10.3747/co.v17i5.593
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Case Report

A Rare Adverse Skin Reaction after 8 Gy of Radiation Therapy to the Thoracic Spine: Case Report and Review of the Literature

by
G. Mitera
1,*,
G. Chan
2,
K. Mah
2,
R. Law
3,
C. DeAngelis
3,
R. Dent
4 and
E. Chow
1
1
Rapid Response Radiotherapy Program, Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
2
Department of Medical Physics, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
3
Department of Pharmacy, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
4
Department of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2010, 17(5), 70-73; https://doi.org/10.3747/co.v17i5.593
Submission received: 9 July 2010 / Revised: 6 August 2010 / Accepted: 3 September 2010 / Published: 1 October 2010

Abstract

A 60-year-old woman with breast cancer metastatic to the bones experienced no adverse skin reaction at the lumbar spine after a single 8-Gy photon-beam fraction prescribed to a depth of 5 cm. However, a subsequent treatment to the thoracic spine using the same dose, fractionation, and technique resulted in skin erythema and permanent hyperpigmentation. After careful investigation, no differences were identified in her concurrent use of possibly radiosensitizing medications during the various radiotherapy treatments nor in possible errors of treatment planning and radiation delivery. To our knowledge, this is the first case report to document that, with similar medications, a previous skin response to a given radiotherapy dose, fraction, and technique may not be predictive of subsequent skin response to similar radiotherapy.
Keywords: acute side effects; bone metastases; hyperpigmentation; palliative radiation; radiation dermatitis acute side effects; bone metastases; hyperpigmentation; palliative radiation; radiation dermatitis

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MDPI and ACS Style

Mitera, G.; Chan, G.; Mah, K.; Law, R.; DeAngelis, C.; Dent, R.; Chow, E. A Rare Adverse Skin Reaction after 8 Gy of Radiation Therapy to the Thoracic Spine: Case Report and Review of the Literature. Curr. Oncol. 2010, 17, 70-73. https://doi.org/10.3747/co.v17i5.593

AMA Style

Mitera G, Chan G, Mah K, Law R, DeAngelis C, Dent R, Chow E. A Rare Adverse Skin Reaction after 8 Gy of Radiation Therapy to the Thoracic Spine: Case Report and Review of the Literature. Current Oncology. 2010; 17(5):70-73. https://doi.org/10.3747/co.v17i5.593

Chicago/Turabian Style

Mitera, G., G. Chan, K. Mah, R. Law, C. DeAngelis, R. Dent, and E. Chow. 2010. "A Rare Adverse Skin Reaction after 8 Gy of Radiation Therapy to the Thoracic Spine: Case Report and Review of the Literature" Current Oncology 17, no. 5: 70-73. https://doi.org/10.3747/co.v17i5.593

APA Style

Mitera, G., Chan, G., Mah, K., Law, R., DeAngelis, C., Dent, R., & Chow, E. (2010). A Rare Adverse Skin Reaction after 8 Gy of Radiation Therapy to the Thoracic Spine: Case Report and Review of the Literature. Current Oncology, 17(5), 70-73. https://doi.org/10.3747/co.v17i5.593

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