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Current Oncology
Volume 17
Issue 4
10.3747/co.v17i4.571
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up

by
A. Nahal
1,*,
A. Ajlan
2,
T. Alcindor
3 and
R. Turcotte
4
1
Department of Pathology, McGill University Health Center, Montreal, QC, Canada
2
Department of Radiology, McGill University Health Center, Montreal, QC, Canada
3
Departments of Oncology and Medicine, McGill University Health Center, Montreal, QC, Canada
4
Division of Orthopedic Surgery, McGill University Health Center, Montreal, QC, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2010, 17(4), 71-76; https://doi.org/10.3747/co.v17i4.571
Submission received: 4 May 2010 / Revised: 8 June 2010 / Accepted: 6 July 2010 / Published: 1 August 2010

Abstract

Giant cell tumour (GCT) of bone is a locally aggressive benign tumour. It can, however, undergo dedifferentiation, either de novo or secondarily after local recurrence or radiation. Whether spontaneously occurring or induced by previous irradiation, this malignant transformation is typically defined as a high-grade anaplastic sarcoma devoid of giant cells. Dedifferentiation of GCT into low-grade-appearing sarcoma has not been reported yet. Here, we describe the first case of dedifferentiated GCT in the appearance of low-grade fibroblastic osteogenic sarcoma with distant bone metastases. This disease progression occurred without previous irradiation. We confirm the aggressive behaviour of this tumour despite the deceptively bland appearance of the malignant component. We also alert others to the importance of recognizing this rare histology to avoid underdiagnosis and subsequent undertreatment.
Keywords: giant cell tumour; malignancy; osteogenic sarcoma; dedifferentiation giant cell tumour; malignancy; osteogenic sarcoma; dedifferentiation

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MDPI and ACS Style

Nahal, A.; Ajlan, A.; Alcindor, T.; Turcotte, R. Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up. Curr. Oncol. 2010, 17, 71-76. https://doi.org/10.3747/co.v17i4.571

AMA Style

Nahal A, Ajlan A, Alcindor T, Turcotte R. Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up. Current Oncology. 2010; 17(4):71-76. https://doi.org/10.3747/co.v17i4.571

Chicago/Turabian Style

Nahal, A., A. Ajlan, T. Alcindor, and R. Turcotte. 2010. "Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up" Current Oncology 17, no. 4: 71-76. https://doi.org/10.3747/co.v17i4.571

APA Style

Nahal, A., Ajlan, A., Alcindor, T., & Turcotte, R. (2010). Dedifferentiated Giant Cell Tumour of Bone in the Form of Low-Grade Fibroblastic Osteogenic Sarcoma: Case Report of a Unique Presentation with Follow-Up. Current Oncology, 17(4), 71-76. https://doi.org/10.3747/co.v17i4.571

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