1. Introduction
Myopia has recently been focused on as a global health issue [
1]. It used to be an issue for only a limited number of people half a century ago. However, in East Asian countries, the myopia population has grown fourfold in the last 60 years [
2]. In those countries, the majority of children are myopic, as if it were a pandemic. Indeed, it is predicted that half of the world’s population will be myopic in 2050 [
3].
Myopia occurs as the eyeball grows to the extent that the incident light is focused in front of the retina, resulting in blurred vision. With the excessive elongation of the eyeball’s axial length, a high degree of myopia is a risk factor for potential visual impairment, including blindness [
4,
5,
6]. Although the cause of myopia has not been clearly identified, several strategies can be used against myopia [
7]. Orthokeratology was invented and has been used in some countries. Orthokeratology hard contact lenses correct the shape of the corneal surface while sleeping, which in turn releases users from corrective devices during the day. Low-concentration atropine drops have been widely used for suppressive effects [
8]. Clinical trials of the MiyoSmart contact lens by HOYA were completed, and the product entered the market in Hong Kong [
9]. Clinical trials of the MiSight contact lens by Cooper Vision were completed, and the product is available in the U.S. and several other countries [
10].
Various studies have largely agreed on the importance of the light environment [
11]. The light intensity varies extensively in daily life from 0.1-lux-level moonlight [
12] to up-to 100,000-lux-level sunlight. The human eye has a wide range of sensitivity, and one does not feel any inconvenience, whether outdoors or indoors. Rose et al. [
11] proved that although near-work activities are normally considered negative to the eye, they have a smaller effect on the odds ratio of myopia as long as high levels of outdoor activities are maintained. From the extensive Recess Outside Classroom Trial 711 (ROCT711) program of Taiwan, a moderate amount of light intensity such as 1000 lux was found to be sufficient to show a protective effect against myopia with a longer duration than the brighter 10,000-lux case [
13].
The Sun emits a broad spectrum of electromagnetic radiation, ranging from ultraviolet (UV) to infrared, with visible light spanning approximately 360 to 830 nm. The intensity distribution within this spectrum varies, with the highest energy concentrated in the visible and near-infrared ranges. In the Result section of this article, we illustrate the solar radiation spectra, highlighting the proportion of different wavelengths, including violet light (VL).
Violet light (VL) is part of the shortest-wavelength region of the visible spectrum, with wavelengths ranging from approximately 360 to 400 nm. While VL is present in natural sunlight, it is significantly reduced indoors due to modern architectural materials and lighting designs. According to the International Lighting Vocabulary by the Commission Internationale de l’Eclairage (CIE), the lower limit of visible light is defined as 360 nm [
14]. Although VL falls within the visible spectrum, its perception is limited due to the human spectral luminous efficiency curve, which peaks in the green range and declines toward both spectral ends. Furthermore, the human cornea and lens exhibit low transmittance for wavelengths below 400 nm, a characteristic that becomes more pronounced with age [
15,
16]. As a result, only a small proportion of VL reaches the retina.
Beyond its role in vision, recent studies suggest that VL exposure influences circadian rhythm regulation, mood stabilization, and potential skin-related photobiological effects [
17,
18,
19,
20,
21,
22]. However, modern indoor environments significantly limit VL exposure due to the widespread use of UV-blocking materials, which may have broader physiological implications.
In addition to these general health effects, VL has been specifically implicated in the regulation of eye growth and myopia progression. In 2017, we reported that VL displayed a suppressive effect against myopia progression in chicks and humans [
23]. Other studies have observed the same protective effect of VL in mice [
24,
25]. However, most prior studies have been conducted in controlled laboratory settings using animal models. While these studies provided valuable mechanistic insights, the extent to which VL exposure in real-world environments influences myopia progression remains unclear.
VL can be found in nature and in artificial lighting sources. Some materials transmit VL, whereas others do not. With a few examples, we have previously shown that VL exists abundantly outside in sunlight, whereas it is eliminated indoors in our modern lifestyle due to various so-called UV-protecting objects [
23,
26]. This study aims to systematically quantify VL availability in various indoor and outdoor settings, providing a comprehensive assessment of VL exposure under different environmental conditions and its implications for myopia prevention.
2. Materials and Methods
2.1. Measurement Devices Used
The spectral irradiance was measured using a fiber-optic spectrometer (BLUE-Wave, UVNb-50, StellarNet Inc., Tampa, FL, USA). The instrument had a 50 μm slit width, and the predicted resolution was 1.6 nm. The probe tip was installed with a light diffuser with a 180° field of view. The spectrometer and probe were calibrated for wavelength and intensity using the NIST-compliant method of the manufacturer. The spectrometer covers the wavelength range from UV to near-infrared. The measurement data were saved as a text file on a personal computer connected to the spectrometer. VL irradiance can be calculated by integrating the measured spectral irradiance in the VL wavelength range of 360–400 nm using the rectangular approximation.
The illuminance was measured using an illuminometer LX-1108 (KENIS LIMITED, Osaka, Japan). A dome-like light diffuser was used as the measurement probe. Data were recorded manually.
2.2. Measurements
For measurements, the probe was directed toward a light source or toward a certain direction, mimicking the human eye. For outdoor measurements, sunlight spectral irradiance data were collected at Keio University Shinanomachi Campus, Tokyo. Three different summer dates were chosen for the measurements without any particular intention, but the measurement time was all during the day when the Sun was high on the sky. The ground is a road paved with asphalt. The site was surrounded by buildings from which the horizon was not visible, which is a typical situation in Tokyo and other cities in developed countries. The weather was mostly cloudy on 5 July 2017, and the measurements were conducted at 14:30, 15:30, and 16:30 local time. It was again cloudy on the second day of 6 July 2017. The measurements were conducted three times in the morning at 10:00, 11:00, and 12:00. On the third day, 9 August 2017, it was mostly sunny with only a few clouds that did not block the Sun. On this day, four time slots, 11:00, 12:00, 13:00, and 14:00, were chosen for the measurements. For all sunlight measurements, the probe was pointed horizontally toward the four cardinal points, north, south, east, and west. Additionally, the Sun was measured with the probe pointed directly. On cloudy days, the Sun was behind the cloud, but the probe was directed toward the Sun.
While lighting fixtures were measured in our previous study [
23], we measured two kinds of displays that are other representative emitting devices in this study. The iPhone (model: iPhone 6 plus) smartphone had a liquid-crystal display (LCD). The screen was set in white with 100% brightness and was measured by the probe 30 cm away from the display surface without any filter. The other display was LG’s organic light-emitting diode (OLED) television (TV) (model: OLED55C8PJA). The white screen was again measured at a distance of 30 cm.
In addition to emitting objects, we measured several transmitting objects with the Sun as the light source. As the two most representative ones, window glass and eyeglass lenses of different characteristics, but all clear in color, were chosen for spectral measurements. This is not a transmittance measurement of an object but a spectrum through a lens with the Sun as the lighting source. The indoor environment of a German automobile (BMW 435i) was measured through the front and side windows on a partly cloudy day on 11 June 2015, while it was being driven on a street in Tokyo, Japan. Indoor sunlight spectra were also measured on the same day in a modern condominium room in Tokyo through a window and lace curtain. School classrooms with windows of different transparent characteristics were measured. One school was a junior high school in Fujisawa, Kanagawa, Japan (measurement date: 13 April 2015), and the other was a kindergarten in Tokyo (measurement date: 16 December 2015). To study the position dependence of the incoming sunlight intensity from the window, both VL irradiance and illuminance were measured at equally spaced positions with the measuring probe pointing in the direction of the arrow. Note that fluorescent lights on the ceiling were kept on during the measurements in the classrooms.
Spectral irradiance was measured using three different eyeglass lenses on a cloudy day on 6 September 2017, in Tokyo. The three types of eyeglass lenses are a glass trial lens (Takagi Seiko Co., Ltd., Nagano, Japan), a plastic lens (JINS HOLDINGS Inc., Tokyo, Japan), and a VL-transmitting plastic lens (“JINS VIOLET+”, JINS HOLDINGS Inc., Tokyo, Japan).
4. Discussion
The Sun is the ultimate lighting source. As detected in our outdoor measurements, sunlight has a broad spectrum, ranging from UV-B to infrared, including VL, and is very intense. The Sun delivers sufficient energy to the ground. By integrating the spectrum for all wavelengths, one can find the order of 100 k μW/cm
2 sunlight power delivered to the ground. VL, defined for wavelengths from 360 to 400 nm, occupies only approximately 3% of the power of the entire spectrum. Facing the Sun directly at midday when there were no clouds, 3000 μW/cm
2 or more VL was obtained, as shown in
Figure S1. However, for safety reasons, we normally do not look up at the Sun, keeping the line of sight approximately horizontal, which limits the incident VL that enters the eye.
Our previous study [
23] showed that VL is abundant outdoors but significantly reduced indoors due to UV-blocking materials, with negligible exposure in windowless rooms and very low levels even with windows. However, it did not consider the impact of directional factors on VL exposure. In contrast, our current study systematically quantifies VL in various real-life settings, including classrooms, and examines the influence of directional factors (north, south, east, and west). These findings highlight how VL availability depends not only on indoor conditions but also on external environmental factors, further emphasizing the severe deficiency of VL in modern indoor settings.
The effects of VL exposure on myopia suppression have been studied in both animal models and human clinical trials. Jeong et al. [
28] demonstrated in a murine myopia model that VL transmission ratios influenced myopia progression, with significant suppression observed at VL transmittance levels of 70% and above, whereas 40% transmittance showed only minor effects. This suggests a potential threshold for VL exposure necessary to elicit a biological response in myopia control. In human studies, a randomized controlled trial by Mori et al. [
29] demonstrated that VL-transmitting eyeglasses significantly reduced axial elongation over a two-year period, with no reported adverse effects. This suggests that moderate VL exposure is not only effective in suppressing myopia progression but also safe for long-term use. Given the substantial reduction in VL indoors due to modern architectural materials, future studies should aim to determine the minimum effective dose of VL required to achieve meaningful myopia suppression in humans while ensuring safety.
The average VL irradiance of 310 μW/cm2 obtained in the previous section was called a yearly average, to the extent that the weather statistics used was a yearly figure. However, as there is no seasonal information, it is not ideal to combine these statistics with the underlying measurement results of only summer. The average also presents a fundamental difficulty with the measurement scheme. The amount of measurement data should be sufficiently large, but the sky is too dynamic to capture the state of the moment. Consequently, irradiation can constantly change at any given moment. The average irradiance could also be found from continuous measurements over time by dividing the irradiated energy by the exposure time. If this type of continuous measurement is repeated over a long period of time for different seasons of the year, the quality of the average figure becomes better and closer to the true yearly average. The measurement location was just one place in Tokyo. Thus, the results might not be applicable in other parts of the world. Our current results are not conclusive at least quantitatively, requiring us to conduct further studies for statistically better results. Nevertheless, they should well reflect the circumstances of similar developed countries.
In our modern lifestyle, there are almost no artificial lighting sources that provide VL, with a few exceptions. Following the first-generation artificial lighting source of candles, the incandescent lamp from the last century is called the second-generation household lamp, and it has low VL [
23]. Fluorescent lamps (third generation) and LED lights (fourth generation) have no VL included in their emitted white light. Therefore, if we were to take VL indoors, we must make the VL component of the sunlight come indoors, or an artificial VL lighting source such as a VL LED should be used.
Our modern lifestyle is surrounded by various so-called “UV-protecting” items that block not only ultraviolet light, but also VL. These are high-pass filters, leaving out the low-wavelength components. Visible light transmits these UV-protecting items, thereby producing white light. As far as types of window glass are concerned, relatively old and new UV-protecting window glass coexist in our current society. The old and simple type of window glass permits VL transmission, and it is still being used in buildings equipped with “standard” glass. Nevertheless, the trend toward UV protection has accelerated. UV protection is an additional added value to special interior spaces. For example, our previous study reported a sharp drop in sunlight spectral irradiance at 400 nm in motor vehicles and modern buildings [
23]. In contrast, the sunlight component down to a wavelength of 350 nm, including VL, penetrated through the side window of the vehicle (orange line in
Figure 3A) and also through the condominium room window (blue line in
Figure 3B). Over such a window, the curtain provided extra UV protection in the room, increasing the cut-off wavelength to 400 nm, and therefore transmitting no VL indoors.
In addition, other UV-protecting items that can be found in society are lenses to the eye. Current eyeglass lenses are made of plastic, and with extra surface coating, the so-called UV400 requirement is met [
30].
Figure 5 clearly indicates that the short-wavelength end of the sunlight spectrum is truncated by the different types of eyeglass lenses. A glass lens with a cut-off wavelength of 330 nm was used only as a trial lens and not for eyeglasses. A UV400 lens is a typical choice for current users. The VL transmitting lens was situated between these two lenses.
It has been recently shown that VL, the shortest-wavelength visible light, plays an important role in protecting the eye from myopic progression [
23,
26]. There is unfortunate bias and confusion surrounding the term ultraviolet (UV), as it is often used based on convention rather than strict optical visibility. The most natural definition of UV is that it begins where light becomes invisible as its wavelength decreases. Following this principle, the shortest visible light is violet (VL), and the adjacent, non-visible range is ultraviolet (UV). The Commission Internationale de l’Eclairage (CIE), which formally defines visible light, states that the shortest-wavelength visible radiation extends down to 360 nm [
14].
However, another classification—widely used in safety standards—defines UV as encompassing wavelengths up to 400 nm, dividing it into three subcategories: UV-A (315–400 nm), UV-B (280–315 nm), and UV-C (below 280 nm) [
31]. This classification is the basis for the widely known UV400 standard and many UV-blocking materials, which often filter out not only UV but also a portion of VL [
30].
From a photobiological safety perspective, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) provides guidelines [
32] for exposure limits to ultraviolet radiation, including UV-A (315–400 nm). These guidelines are designed to ensure safety against acute phototoxic effects, though they do not directly address the chronic effects of long-term exposure. Importantly, while VL is defined by CIE [
14] as the shortest-wavelength visible light (360–400 nm), ICNIRP classifies VL as falling within the UV-A range based on its wavelength range rather than its visibility. Although our estimated VL irradiance is significantly lower than ICNIRP’s recommended exposure limits for UV radiation, prolonged direct sun exposure, particularly in extreme conditions, may pose different risks and should be considered separately.
An additional interesting characteristic was found in our school-classroom measurements. The window glass was all UV-protected in junior high schools. Only negligibly small or zero VL values were found indoors. As depicted in
Figure 4A, the illuminance measured in the front direction came from the fluorescent lamps on the ceiling and the Sun through two windows located at the front and back of the classroom. In contrast, the kindergarten was equipped with old-fashioned window glass, which allowed VL to enter the classroom. However, as illustrated in
Figure 4B,C, the VL power measured at different positions inside the classroom decreased quickly as it was farther from the window, with the Sun present outside at the time of measurements. The measured illuminance behaved similarly in the same classroom, decreasing according to the distance from the window, in the direction of the Sun. The illuminance was again measured for the two white light sources, as in the junior high school case. As VL irradiance decreased, the measured illuminance also decreased. The room was kept sufficiently bright in terms of the illuminance. However, we did not recognize the rapidly diminishing VL or even the presence or absence of VL in the room because of the low VL sensitivity of the eye.
5. Conclusions
Despite the widely varying weather and consequent change in intensity, the brightness of sunlight is normally much stronger than that of artificial lighting sources, such as lamps and displays. VL is abundant outdoors under sunlight. An average VL irradiance of 310 μW/cm2 was determined using a weighted calculation under basic assumptions. Exposing the eye to this much VL power for two or three hours could prevent myopic eyes from worsening.
Once one goes indoors, VL can hardly be found, except near the window with VL-transmitting glass, because of the prevalent UV-protecting items. Moreover, among the ordinary household lighting sources currently available, there are no VL-emitting lighting sources. Therefore, one must rely on sunlight as the source of VL, and to have the naked eye receive or wear VL-transmitting lenses to receive VL.
Given these findings, future efforts should focus on designing architectural solutions that allow for greater VL transmission indoors, such as optimized window coatings and specialized daylighting strategies. Additionally, advancements in artificial lighting technology, including VL-emitting LEDs, could help compensate for the lack of natural VL exposure in indoor environments. These innovations could play a crucial role in mitigating VL deficiency and potentially contribute to myopia prevention.
If VL-transmitting and VL-emitting items are to be developed, their safety and efficacy should be thoroughly studied for potential use in myopia prevention.