PEEP-ZEEP Compared with Bag Squeezing and Chest Compression in Mechanically Ventilated Cardiac Patients: Randomized Crossover Clinical Trial
Abstract
:1. Introduction
2. Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | N = 36 (%) |
---|---|
Age * | 70.3 ± 10.6 |
Sex | |
Female | 15 (10.4) |
Male | 21 (14.6) |
BMI | |
Underweight | 4 (2.8) |
Normal | 12 (8.3) |
Overweight | 7 (4.9) |
Obesity | 12 (8.3) |
Risk factors | |
Smoking | 14 (9.7) |
Hypertension | 29 (20.1) |
Diabetes mellitus | 17 (11.8) |
Dyslipidemia | 26 (18.1) |
Reason for hospitalization | |
Ischemic heart disease | 15 (10.4) |
Dilated cardiomyopathy | 2 (1.4) |
Valve disease | 6 (4.2) |
PAD | 3 (2.1) |
Decompensated heart failure | 1 (0.7) |
Others | 5 (3.5) |
Associated diseases | |
Ischemic heart disease | 4 (2.8) |
Kidney disease | 15 (10.4) |
CAD | 8 (5.6) |
Arrhythmias | 7 (4.9) |
Others | 20 (13.9) |
Cardiac surgery | |
Total postoperative | 4 (2.8) |
Complications during hospitalization | |
Cardiopulmonary arrest | 14 (9.7) |
Arrhythmias | 10 (6.9) |
Respiratory failure | 9 (6.3) |
Cardiogenic shock | 5 (3.5) |
APE | 6 (4.2) |
Others | 16 (11.1) |
MV days * | 5.3 ± 3.1 |
Drug class used | |
Vasoactive drug | 17 (11.8) |
Sedatives | 15 (10.4) |
Antibiotics | 32 (22.2) |
Anticoagulants | 6 (4.2) |
Others | 3 (2.1) |
Variable | N = 36 (%) | |
---|---|---|
VM Mode | Control Group | Intervention Group |
PCV | 13 (41.9) | 12 (40.0) |
VCV | 5 (16.1) | 5 (16.7) |
PSV | 11 (35.5) | 9 (30) |
IPPV | 2 (6.5) | 4 (13.3) |
Ventilation adjustment | ||
PEEP * | 6.9 ± 1.3 | 6.7 ± 1.1 |
FiO2 * | 35.1 ± 13.2 | 35.3 ± 12.9 |
Control Group (N = 27) | Intervention Group (N = 29) | Group | Time | G*M | |||
---|---|---|---|---|---|---|---|
Variable | Before | After | Before | After | p Value | ||
SBP (mmHg) * | 121 ± 3.6 | 129.1 ± 4.2 | 119.2 ± 4.7 | 126.2 ± 6.2 | 0.592 | 0.083 | 0.845 |
DBP (mmHg) * | 64.7 ± 2.5 | 72.2 ± 3.8 | 64.7 ± 2.7 | 69.5 ± 3.3 | 0.631 | 0.024 | 0.609 |
MAP (mmHg) * | 82 ± 2.1 | 90 ± 3.1 | 79.9 ± 2.4 | 87.9 ± 4 | 0.428 | 0.004 | 0.998 |
HR (bpm) * | 92 ± 4.5 | 94.4 ± 3.6 | 92.8 ± 4.3 | 98.9 ± 3.7 | 0.386 | 0.173 | 0.299 |
SpO2 (%) * | 97.3 ± 0.4 | 97.6 ± 0.4 | 96.5 ± 0.5 | 96.8 ± 0.6 | 0.210 | 0.394 | 0.903 |
RR (bpm) * | 22 ± 0.8 | 22.4 ± 0.9 | 21 ± 0.7 | 22.8 ± 0.6 | 0.798 | 0.041 | 0.154 |
Control Group (N = 27) | Intervention Group (N = 29) | Group | Moment | G*M | |||
---|---|---|---|---|---|---|---|
Variable | Before | After | Before | After | p Value | ||
TV * | 425.19 ± 11.9 | 443.1 ± 14.3 | 410.7 ± 11.7 | 442.5 ± 18.9 | 0.384 | 0.052 | 0.479 |
PPeak * | 20.9 ± 0.9 | 19.7 ± 0.9 | 21.4 ± 1.1 | 20.8 ± 1.0 | 0.202 | 0.011 | 0.333 |
P Plateau * | 18.5 ± 0.9 | 18.9 ± 0. 8 | 18.3 ± 0.9 | 18.4 ± 0.8 | 0.640 | 0.644 | 0.787 |
DP * | 11.50 ± 0.7 | 11.52 ± 7.6 | 11.4 ± 0.9 | 12 ± 0.8 | 0.701 | 0.518 | 0.531 |
Cst * | 36.5 ± 2. 8 | 36.3 ± 2.6 | 37.3 ± 3.7 | 35.2 ± 3.7 | 0.963 | 0.373 | 0.597 |
Cdyn * | 26.9 ± 1.9 | 33.8 ± 2.7 | 30.3 ± 3.6 | 29.4 ± 4.4 | 0.902 | 0.122 | 0.004 |
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de Oliveira, T.F.; Peringer, V.S.; Forgiarini Junior, L.A.; Eibel, B. PEEP-ZEEP Compared with Bag Squeezing and Chest Compression in Mechanically Ventilated Cardiac Patients: Randomized Crossover Clinical Trial. Int. J. Environ. Res. Public Health 2023, 20, 2824. https://doi.org/10.3390/ijerph20042824
de Oliveira TF, Peringer VS, Forgiarini Junior LA, Eibel B. PEEP-ZEEP Compared with Bag Squeezing and Chest Compression in Mechanically Ventilated Cardiac Patients: Randomized Crossover Clinical Trial. International Journal of Environmental Research and Public Health. 2023; 20(4):2824. https://doi.org/10.3390/ijerph20042824
Chicago/Turabian Stylede Oliveira, Taís Flores, Vinicius Serra Peringer, Luiz Alberto Forgiarini Junior, and Bruna Eibel. 2023. "PEEP-ZEEP Compared with Bag Squeezing and Chest Compression in Mechanically Ventilated Cardiac Patients: Randomized Crossover Clinical Trial" International Journal of Environmental Research and Public Health 20, no. 4: 2824. https://doi.org/10.3390/ijerph20042824