Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities
Abstract
:1. Introduction
2. Pathogenesis of Neurodegenerative Diseases
2.1. Role of Neurotransmitters and Neuronal Hormones in the Pathogenesis of Neurodegenerative Diseases
2.2. Implications of Environment and Climate Influences on Neurotransmitters and Neuronal Hormones Activities
2.3. Impact of Environment on Neurodegenerative Diseases
2.3.1. In Utero Conditions
2.3.2. Exposure to Metals and Pesticides
2.3.3. Chemo Transmission in the Extracellular Environment
2.4. Impact of Climate on Neurodegenerative Diseases
3. Managing Environmental and Climatic Influences in NDDs
3.1. Pharmacological Approaches
3.2. Non-Pharmacological Approaches
4. Conclusion and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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NDDs | Neurological Hormones/ Neurotransmitters | Agonist | Antagonist | Precursors | Metabolism | Biosynthesis | Receptors | Modulator | References |
---|---|---|---|---|---|---|---|---|---|
Alzheimer Parkinson’s Dementia | Acetylcholine | Nicotine Muscarine Cholinesterase inhibitors | Tubocurarine Atropine | Choline Acetyl-CoA | Choline acetyltransferase | Acetylcholinesterase/Role in neuronal activation of the adrenergic system | Nicotinic Muscarinic | Galantamine, Rivastigmine, Donepezil | [74,75,76] |
Dopamine | Apomorphine Amphetamine | Neuroleptics Domperidone | Phenylalanine Tyrosine L-DOPA | Monoamine oxidases (MAO) Catechol-O-methyl transferase (COMT) | DOPA decarboxylase/ DA converges to modulate nuclear factor erythroid 2-like2 (Nrf2) | G protein-coupled receptors/ D1-D5 TAAR | Bromocriptine, Pergolide, lisuride, Cabergoline, Ropinirole, Pramipexole Safinamide | [77,78,79] | |
Serotonin | Azapirones Triptans | Trazodone Nefazodone | 5-HTP Cation channel | MAO | Aromatic L-amino acid decarboxylase Anxiolytics: buspirone MAOI: Furazolidone, Isocarboxazid, linezolid, phenelzine, selegiline, and tranylcypromine | G protein-coupled receptors 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7 | Citalopram, Escitalopram, Fluoxetine, Paroxetine, Sertraline (Zoloft), Clemizole, Locaserin, Trazodone and Fenfluramine | [80,81,82] | |
Melatonin | Ramelteon | Luzindole | Serotonin (5-hydroxytryptamine);N-acetylserotonizn | 6-hydroxymelatonin (6-HMEL | MT1 MT2 receptors | Meladox Melatin Melatonin | [83,84] | ||
Histamine | 2-Pyridylethylamine Betahistine Histamine, HTMT, L-Histidine, UR-AK49 | 4-Methyldiphenhydramine, Alimemazine Antazoline Azatadine | Histidine | Diamine oxidase (DAO) Histamine-N-methyltransferase (HNMT) | Decarboxylation of L-histidine by histidine decarboxylase (HDC) | H1–H4 receptors | Cetirizine, Fexofenadine, Cyproheptadine, fish, cheese, fermented meat, beverages, and vegetables | [85] | |
Epinephrine | Amidephrine Anisodamine Anisodine Cirazoline | Propranolol Phentolamine | Dopamine | MAO COMT | Catecholamine pathway Phenylethanolamine N-methyltransferase | Adrenergic (α and β) receptors | Micronefrin, Nephron, VapoNefrin | [85] | |
Norepinephrine | Sympathomimetic drugs Clonidine Isoprenaline Antagonists | Tricyclic antidepressants Beta-blockers Antipsychotics | Dopamine | MAO-A COMT | Dopamine β-monooxygenase | Adrenergic (α and β) receptors | Atomoxetine, Reboxetine, viloxazine | [86] | |
Thyroid hormones | Sobetirome (GC-1) | 7 transmembrane-spanning receptor (7TMR) | T0–T4 | Glucuronidation, sulfation and deiodination (type 1 (D1), type 2 (D2) and type 3 (D3) iodothyronine deiodinases | The interface of the apical thyroid cell plasma membrane and the colloid, and TG molecules containing T4 and T3 are stored in the follicle lumen | THRA1, THRA2, ERBA1 | L-thyroxin (T4); 3, 3′,5-triiodo-L-thyronine (T3) | [87,88] | |
Tyrosine | Amidephrine Anisodine Buspirone Cirazoline | Axitinib Dasatinib Erlotinib Imatinib Nilotinib | Alkaloid (Morphine; p-coumaric acid) Pigments (melanin) | L-DOPA via tyrosine hydroxylase (TH) | Phenylalanine by phenylalanine hydroxylase | Insulin receptor, Vascular endothelial growth factor Fibroblast growth factor Platelet-derived growth factor receptor | L-tyrosine, Levothroid, Levoxyl, Synthroid | [89,90] | |
Encephalopathy Parkinson’s Huntington’s | Glutamate | Kainic acid | N-methyl-d-aspartate (NMDA) | N-acetyl-L-glutamate δ-1-Pyrroline-5-carboxylate β-citryl glutamate L-γ-glutamyl-L-cysteine | Glutamate to N-acetyl-L-glutamate by N-acetyl glutamate synthase (NAGS) and triggered by L-arginine by succinate, CoA, N-acetyl-L-aspartate N-acetyl-L-Glutamate γ –aminobutyrate Glutathiones | L-proline L-arginine | α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPA) Kainic acid receptors; N-methyl-D-aspartate receptor (NMDA) | GLYX-13, NRX-1074, CERC-301 (MK-0657), Esketamine (Ketanest S) Lanicemine. | [91,92,93] |
Gamma-aminobutyric acid | Muscimol Baclofen | Bicuculline Gabazine Flumazen | Glucose to Glutamate via TCA enzyme Pyruvate Glutamine | GABA transaminase converted to 4-amino butanoic acid (GABA) and α-ketoglutarate to succinic semialdehyde and Glutamate | Glutamate by glutamate decarboxylase (GAD) via pyridoxal phosphate | GABA (A-C) | Benzidiazepines e.g diazepam and alprazolam | [94,95] | |
Glycine | β-alanine L- Serine D- Serine L-Proline Taurine | Brucine Caffeine Picrotoxin Strychnine | Glutathione Porphyrins Purines Haem Creatine | L-serine via glycine hydroxyl-methyltransferase | Serine Threonine Choline Hydroxyproline | Glycine receptors (GLRA1, GLRA2, GLRA3, GLRA4) and a single β-subunit (GLRB) | D-cycloserine, (R,S)-ketamine | [96,97] | |
Alzheimer Parkinson Ischemia-reperfusion Anxiety | Nitric oxide | S-Nitroso-N-acetyl-DL-penicillamine | 3-Bromo-7-nitroimidazole N-N-dimethylarginine | L-arginine L-citrulline | Cysteine S-nitrosylation Thiol amino acids | NOS neuronal (nNOS) NOS inducible (iNOS) Endothelial NOS (eNOS) | Guanylyl cyclase | INomax | [98] |
Hydrogen sulfide | Trimebutine | Glibenclamide | Methanethiol Ethanethiol Thioglycolic acid. | Cystathionine γ-lyase (CSE) Cystathionine β-synthetase (CBS) 3-mercaptopyruvate sulfurtransferase (3-MST) | L-cysteine cystathionine γ-lyase Cystathionine β-synthase (CBS) 3-mercaptopyruvate-sulfurtransferase Aspartate Aminotransferase D-cysteine D-amino acid oxidase (DAO) | NMDA receptors | [99] |
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Ayeni, E.A.; Aldossary, A.M.; Ayejoto, D.A.; Gbadegesin, L.A.; Alshehri, A.A.; Alfassam, H.A.; Afewerky, H.K.; Almughem, F.A.; Bello, S.M.; Tawfik, E.A. Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities. Int. J. Environ. Res. Public Health 2022, 19, 12495. https://doi.org/10.3390/ijerph191912495
Ayeni EA, Aldossary AM, Ayejoto DA, Gbadegesin LA, Alshehri AA, Alfassam HA, Afewerky HK, Almughem FA, Bello SM, Tawfik EA. Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities. International Journal of Environmental Research and Public Health. 2022; 19(19):12495. https://doi.org/10.3390/ijerph191912495
Chicago/Turabian StyleAyeni, Emmanuel A., Ahmad M. Aldossary, Daniel A. Ayejoto, Lanre A. Gbadegesin, Abdullah A. Alshehri, Haya A. Alfassam, Henok K. Afewerky, Fahad A. Almughem, Saidu M. Bello, and Essam A. Tawfik. 2022. "Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities" International Journal of Environmental Research and Public Health 19, no. 19: 12495. https://doi.org/10.3390/ijerph191912495