Estimated Glomerular Filtration Rate and Hearing Impairment in Japan: A Longitudinal Analysis Using Large-Scale Occupational Health Check-Up Data
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Evaluation of Hearing Impairment
2.3. Evaluation of Renal Function by eGFR
2.4. Definition of Baseline Variables
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- World Health Organization Deafness and Hearing Loss. Available online: https://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss (accessed on 17 August 2022).
- Saito, H.; Nishiwaki, Y.; Michikawa, T.; Kikuchi, Y.; Mizutari, K.; Takebayashi, T.; Ogawa, K. Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese. J. Am. Geriat. Soc. 2010, 58, 93–97. [Google Scholar] [CrossRef] [PubMed]
- Michikawa, T. Prevalence, adverse health, and risk factors in association with sensory impairments: Data from a prospective cohort study of older Japanese. Environ. Health Prev. Med. 2016, 21, 403–409. [Google Scholar] [CrossRef] [PubMed]
- GBD 2019 Hearing Loss Collaborators. Hearing loss prevalence and years lived with disability, 1990–2019: Findings from the Global Burden of Disease Study 2019. Lancet 2021, 397, 996–1009. [Google Scholar] [CrossRef]
- Brant, L.J.; Gordon-Salant, S.; Pearson, J.D.; Klein, L.L.; Morrell, C.H.; Metter, E.J.; Fozard, J.L. Risk factors related to age-associated hearing loss in the speech frequencies. J. Am. Acad. Audiol. 1996, 7, 152–160. [Google Scholar] [PubMed]
- Fischer, M.E.; Schubert, C.R.; Nondahl, D.M.; Dalton, D.S.; Huang, G.-H.; Keating, B.J.; Klein, B.E.K.; Klein, R.; Tweed, T.S.; Cruickshanks, K.J. Subclinical atherosclerosis and increased risk of hearing impairment. Atherosclerosis 2015, 238, 344–349. [Google Scholar] [CrossRef]
- Horikawa, C.; Kodama, S.; Tanaka, S.; Fujihara, K.; Hirasawa, R.; Yachi, Y.; Shimano, H.; Yamada, N.; Saito, K.; Sone, H. Diabetes and risk of hearing impairment in adults: A meta-analysis. J. Clin. Endocr. Metab. 2013, 98, 51–58. [Google Scholar] [CrossRef]
- Nagahama, S.; Kashino, I.; Hu, H.; Nanri, A.; Kurotani, K.; Kuwahara, K.; Dan, M.; Michikawa, T.; Akter, S.; Mizoue, T.; et al. Haemoglobin A1c and hearing impairment: Longitudinal analysis using a large occupational health check-up data of Japan. BMJ Open 2018, 8, e023220. [Google Scholar] [CrossRef]
- Michikawa, T.; Mizutari, K.; Saito, H.; Takebayashi, T.; Nishiwaki, Y. Glycosylated hemoglobin level is associated with hearing impairment in older Japanese: The Kurabuchi Study. J. Am. Geriat. Soc. 2014, 62, 1231–1237. [Google Scholar] [CrossRef]
- Levey, A.S.; Eckardt, K.-U.; Tsukamoto, Y.; Levin, A.; Coresh, J.; Rossert, J.; Zeeuw, D.D.; Hostetter, T.H.; Lameire, N.; Eknoyan, G. Definition and classification of chronic kidney disease: A position statement from kidney disease: Improving global outcomes (KDIGO). Kidney Int. 2005, 67, 2089–2100. [Google Scholar] [CrossRef]
- Liu, W.; Meng, Q.; Wang, Y.; Yang, C.; Liu, L.; Wang, H.; Su, Z.; Kong, G.; Zhao, Y.; Zhang, L. The association between reduced kidney function and hearing loss: A cross-sectional study. BMC Nephrol. 2020, 21, 145. [Google Scholar] [CrossRef]
- Hong, J.W.; Jeon, J.H.; Ku, C.R.; Noh, J.H.; Yoo, H.J.; Kim, D.-J. The prevalence and factors associated with hearing impairment in the Korean adults: The 2010-2012 Korea National Health and Nutrition Examination Survey (observational study). Medicine 2015, 94, e611. [Google Scholar] [CrossRef] [PubMed]
- Seo, Y.J.; Ko, S.B.; Ha, T.H.; Gong, T.H.; Bong, J.P.; Park, D.-J.; Park, S.Y. Association of hearing impairment with chronic kidney disease: A cross-sectional study of the Korean general population. BMC Nephrol. 2015, 16, 154. [Google Scholar] [CrossRef] [PubMed]
- Vilayur, E.; Gopinath, B.; Harris, D.C.; Burlutsky, G.; McMahon, C.M.; Mitchell, P. The association between reduced GFR and hearing loss: A cross-sectional population-based study. Am. J. Kidney Dis. 2010, 56, 661–669. [Google Scholar] [CrossRef] [PubMed]
- Arnold, W. Inner ear and renal diseases. Ann. Otol. Rhinol. Laryngol. Suppl. 1984, 112, 119–124. [Google Scholar] [CrossRef] [PubMed]
- Adler, D.; Fiehn, W.; Ritz, E. Inhibition of Na, K -stimulated ATPase in the cochlea of the guinea pig. A potential cause of disturbed inner ear function in terminal renal failure. Acta Otolaryngol. 1980, 90, 55–60. [Google Scholar] [CrossRef] [PubMed]
- Ohashi, T.; Kenmochi, M.; Kinoshita, H.; Ochi, K.; Kikuchi, H. Cochlear function of guinea pigs with experimental chronic renal failure. Ann. Otol. Rhinol. Laryngol. 1999, 108, 955–962. [Google Scholar] [CrossRef]
- Japan Industrial Safety and Health Association Ordinance on Industrial Safety and Health, Article 44 Periodical Medical Examination, (1) (iii). Available online: https://www.japaneselawtranslation.go.jp/en/laws/view/3878 (accessed on 17 August 2022).
- Matsuo, S.; Imai, E.; Horio, M.; Yasuda, Y.; Tomita, K.; Nitta, K.; Yamagata, K.; Tomita, Y.; Yokoyama, H.; Hishida, A.; et al. Collaborators developing the Japanese equation for estimated, GFR Revised equations for estimated GFR from serum creatinine in Japan. Am. J. Kidney Dis. 2009, 53, 982–992. [Google Scholar] [CrossRef]
- Fukui, A.; Yokoo, T.; Nangaku, M.; Kashihara, N. New measures against chronic kidney diseases in Japan since 2018. Clin. Exp. Nephrol. 2019, 23, 1263–1271. [Google Scholar] [CrossRef]
- Kim, S.H.; Won, Y.S.; Kim, M.G.; Baek, Y.J.; Oh, I.-H.; Yeo, S.G. Relationship between obesity and hearing loss. Acta Otolaryngol. 2016, 136, 1046–1050. [Google Scholar] [CrossRef]
- Hara, K.; Okada, M.; Takagi, D.; Tanaka, K.; Senba, H.; Teraoka, M.; Yamada, H.; Matsuura, B.; Hato, N.; Miyake, Y. Association between hypertension, dyslipidemia, and diabetes and prevalence of hearing impairment in Japan. Hypertens. Res. 2020, 43, 963–968. [Google Scholar] [CrossRef]
- Garcia Morales, E.E.; Ting, J.; Gross, A.L.; Betz, J.F.; Jiang, K.; Du, S.; Power, M.C.; Reed, N.S.; Sharrett, A.R.; Lin, F.R.; et al. Association of Cigarette Smoking Patterns Over 30 Years with Audiometric Hearing Impairment and Speech-in-Noise Perception: The Atherosclerosis Risk in Communities Study. JAMA Otolaryngol. Head. Neck. Surg. 2022, 148, 243–251. [Google Scholar] [CrossRef]
- Dawes, P.; Cruickshanks, K.J.; Moore, D.R.; Edmondson-Jones, M.; McCormack, A.; Fortnum, H.; Munro, K.J. Cigarette smoking, passive smoking, alcohol consumption, and hearing loss. J. Assoc. Res. Otolaryngol. 2014, 15, 663–674. [Google Scholar] [CrossRef]
- Kuo, P.L.; Di, J.; Ferrucci, L.; Lin, F.R. Analysis of Hearing Loss and Physical Activity Among US Adults Aged 60–69 Years. JAMA Netw. Open 2021, 4, e215484. [Google Scholar] [CrossRef]
- Engdahl, B.; Tambs, K. Occupation and the risk of hearing impairment—Results from the Nord-Trondelag study on hearing loss. Scand. J. Work Environ. Health 2010, 36, 250–257. [Google Scholar] [CrossRef]
- Grundy, S.M.; Cleeman, J.I.; Daniels, S.R.; Donato, K.A.; Eckel, R.H.; Franklin, B.A.; Gordon, D.J.; Krauss, R.M.; Savage, P.J.; Smith, S.C., Jr.; et al. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112, 2735–2752. [Google Scholar] [CrossRef]
- Yamagishi, K.; Iso, H. The criteria for metabolic syndrome and the national health screening and education system in Japan. Epidemiol. Health 2017, 39, e2017003. [Google Scholar] [CrossRef]
- Kashiwagi, A.; Kasuga, M.; Araki, E.; Oka, Y.; Hanafusa, T.; Ito, H.; Tominaga, M.; Oikawa, S.; Noda, M.; Kawamura, T.; et al. International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J. Diabetes Investig. 2012, 3, 39–40. [Google Scholar] [CrossRef]
- Cappellini, M.D.; Motta, I. Anemia in Clinical Practice-Definition and Classification: Does Hemoglobin Change with Aging? Semin. Hematol. 2015, 52, 261–269. [Google Scholar] [CrossRef]
- Lien, K.-H.; Yang, C.-H. Sex Differences in the Triad of Acquired Sensorineural Hearing Loss. Int. J. Mol. Sci. 2021, 22, 8111. [Google Scholar] [CrossRef]
- Villavisanis, D.F.; Berson, E.R.; Lauer, A.M.; Cosetti, M.K.; Schrode, K.M. Sex-based Differences in Hearing Loss: Perspectives From Non-clinical Research to Clinical Outcomess. Otol. Neurotol. 2020, 41, 290–298. [Google Scholar] [CrossRef]
- Carrero, J.J.; Hecking, M.; Chesnaye, N.C.; Jager, K.J. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nat. Rev. Nephrol. 2018, 14, 151–164. [Google Scholar] [CrossRef]
- Swartling, O.; Rydell, H.; Stendahl, M.; Segelmark, M.; Lagerros, Y.T.; Evans, M. CKD Progression and Mortality Among Men and Women: A Nationwide Study in Sweden. Am. J. Kidney Dis. 2021, 78, 190–199.e1. [Google Scholar] [CrossRef]
- Gupta, S.; Curhan, S.G.; Cruickshanks, K.J.; Klein, B.E.K.; Klein, R.; Curhan, G.C. Chronic kidney disease and the risk of incident hearing loss. Laryngoscope 2020, 130, E213–E219. [Google Scholar] [CrossRef]
- Levey, A.S.; Inker, L.A.; Coresh, J. GFR estimation: From physiology to public health. Am. J. Kidney Dis. 2014, 63, 820–834. [Google Scholar] [CrossRef]
- Shafi, T.; Zhu, X.; Lirette, S.T.; Rule, A.D.; Mosley, T.; Butler, K.R.; Hall, M.E.; Vaitla, P.; Wynn, J.J.; Tio, M.C.; et al. Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation: A Cross-Sectional Study. Ann. Intern. Med. 2022, 175, 1073–1082. [Google Scholar] [CrossRef]
- Kawakami, R.A.; Sawada, S.S.; Kato, K.; Gando, Y.; Momma, H.; Oike, H.; Miyachi, M.; Lee, I.-M.; Blair, S.N.; Tashiro, M.; et al. A Prospective Cohort Study of Muscular and Performance Fitness and Risk of Hearing Loss: The Niigata Wellness Study. Am. J. Med. 2021, 134, 235–242.e4. [Google Scholar] [CrossRef]
- Lee, J.; Han, K.; Song, J.J.; Im, G.J.; Chae, S.W. Sarcopenia and Hearing Loss in Older Koreans: Findings from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010. PLoS ONE 2016, 11, e0150281. [Google Scholar] [CrossRef]
- Mohammed, S.H.; Shab-Bidar, S.; Abuzerr, S.; Habtewold, T.D.; Alizadeh, S.; Djafarian, K. Association of anemia with sensorineural hearing loss: A systematic review and meta-analysis. BMC Res. Notes 2019, 12, 283. [Google Scholar] [CrossRef]
- Li, C.Y.; Sung, F.C. A review of the healthy worker effect in occupational epidemiology. Occup. Med. 1999, 49, 225–229. [Google Scholar] [CrossRef] [Green Version]
eGFR (mL/min/1.73 m2) Group | |||||
---|---|---|---|---|---|
Overall | ≥90 | 60–89 | <60 | ||
High (≥97.4) | Low (90.0–97.3) | ||||
n (%) | n (%) | n (%) | n (%) | n (%) | |
No. of participants | 88,425 | 12,031 | 12,011 | 61,459 | 2924 |
Age (years) a | 43.6 (8.7) | 37.8 (9.0) | 41.5 (9.2) | 44.7 (8.0) | 50.5 (6.0) |
20s | 6088 (6.9) | 2349 (19.5) | 1449 (12.1) | 2286 (3.7) | 4 (0.2) |
30s | 22,097 (25.0) | 4670 (38.8) | 3413 (28.4) | 13,899 (22.6) | 115 (3.9) |
40s | 35,866 (40.6) | 3635 (30.2) | 4481 (37.3) | 26,679 (43.4) | 1071 (36.6) |
50s | 24,374 (27.5) | 1377 (11.5) | 2668 (22.2) | 18,595 (30.3) | 1734 (59.3) |
eGFR a | 82.7 (14.0) | 106.7 (9.4) | 93.5 (2.2) | 77.2 (7.6) | 54.4 (6.3) |
Body mass index (kg/m2) a | 23.6 (3.7) | 23.1 (4.1) | 23.2 (3.7) | 23.7 (3.5) | 25.0 (3.7) |
<18.5 | 4050 (4.6) | 972 (8.1) | 756 (6.3) | 2277 (3.7) | 45 (1.5) |
18.5–24.9 | 58,389 (66.0) | 8031 (66.7) | 8187 (68.2) | 40,611 (66.1) | 1560 (53.4) |
≥25.0 | 25,986 (29.4) | 3028 (25.2) | 3068 (25.5) | 18,571 (30.2) | 1319 (45.1) |
Hypertension b | 41,139 (46.5) | 4884 (40.6) | 5198 (43.3) | 29,093 (47.3) | 1964 (67.2) |
Dyslipidemia c | 27,140 (30.7) | 3196 (26.6) | 3289 (27.4) | 19,340 (31.5) | 1315 (45.0) |
Diabetes d | 7545 (8.5) | 1151 (9.6) | 1090 (9.1) | 4870 (7.9) | 434 (14.8) |
Hemoglobin A1c (%) a | 5.8 (0.7) | 5.8 (1.0) | 5.8 (0.8) | 5.8 (0.6) | 6.0 (0.7) |
Smoking status | |||||
Nonsmoker | 32,078 (36.3) | 3832 (31.8) | 3816 (31.8) | 23,052 (37.5) | 1378 (47.1) |
Ex-smoker | 14,509 (16.4) | 1368 (11.4) | 1763 (14.7) | 10,725 (17.5) | 653 (22.3) |
≤20 cigarettes/day | 30,205 (34.2) | 4906 (40.8) | 4616 (38.4) | 20,050 (32.6) | 633 (21.7) |
>20 cigarettes/day | 9118 (10.3) | 1632 (13.6) | 1478 (12.3) | 5841 (9.5) | 167 (5.7) |
Unanswered | 2515 (2.8) | 293 (2.4) | 338 (2.8) | 1791 (2.9) | 93 (3.2) |
Alcohol consumption | |||||
Nondrinker | 24,489 (27.7) | 3440 (28.6) | 3146 (26.2) | 16,975 (27.6) | 928 (31.7) |
Occasional drinker | 30,712 (34.7) | 4404 (36.6) | 4212 (35.1) | 21,067 (34.3) | 1029 (35.2) |
Drinker <1 go/day e | 7906 (8.9) | 880 (7.3) | 988 (8.2) | 5779 (9.4) | 259 (8.9) |
Drinker ≥1 go/day e | 22,798 (25.8) | 3018 (25.1) | 3322 (27.7) | 15,843 (25.8) | 615 (21.0) |
Unanswered | 2520 (2.9) | 289 (2.4) | 343 (2.8) | 1795 (2.9) | 93 (3.2) |
Exercise, yes f | 17,652 (20.0) | 2155 (17.9) | 2248 (18.7) | 12,596 (20.5) | 653 (22.3) |
Anemia g | 1414 (1.6) | 210 (1.8) | 155 (1.3) | 919 (1.5) | 130 (4.5) |
Job type | |||||
Professional job | 22,706 (25.7) | 3259 (27.1) | 3078 (25.6) | 15,685 (25.5) | 684 (23.4) |
Management | 10,962 (12.4) | 911 (7.6) | 1233 (10.3) | 8284 (13.5) | 534 (18.3) |
Office job | 11,067 (12.5) | 1244 (10.3) | 1385 (11.5) | 7968 (13.0) | 470 (16.1) |
Sales | 7661 (8.7) | 1302 (10.8) | 1123 (9.4) | 5037 (8.2) | 199 (6.8) |
Service | 3785 (4.3) | 687 (5.7) | 570 (4.8) | 2453 (4.0) | 75 (2.6) |
Telecommunications | 6125 (6.9) | 772 (6.4) | 829 (6.9) | 4301 (7.0) | 223 (7.6) |
Manufacturing | 18,182 (20.6) | 2766 (23.0) | 2695 (22.4) | 12,246 (19.9) | 475 (16.2) |
Other | 5265 (5.9) | 767 (6.4) | 736 (6.1) | 3595 (5.8) | 167 (5.7) |
Unanswered | 2672 (3.0) | 323 (2.7) | 362 (3.0) | 1890 (3.1) | 97 (3.3) |
eGFR (mL/min/1.73 m2) Groups | |||||
---|---|---|---|---|---|
Overall | ≥90 | 60–89 | <60 | ||
High (≥99.6) | Low (90.0–99.5) | ||||
n (%) | n (%) | n (%) | n (%) | n (%) | |
No. of participants | 38,722 | 5743 | 5593 | 26,005 | 1381 |
Age (years) a | 44.4 (9.1) | 38.1 (9.1) | 41.3 (10.2) | 46.1 (8.0) | 51.6 (5.7) |
20s | 2883 (7.5) | 1184 (20.6) | 825 (14.8) | 871 (3.3) | 3 (0.2) |
30s | 8013 (20.7) | 1862 (32.4) | 1714 (30.6) | 4385 (16.9) | 52 (3.8) |
40s | 15,036 (38.8) | 2113 (36.8) | 1528 (27.3) | 11,049 (42.5) | 346 (25.0) |
50s | 12,790 (33.0) | 584 (10.2) | 1526 (27.3) | 9700 (37.3) | 980 (71.0) |
eGFR a | 83.8 (15.3) | 110.0 (10.9) | 94.6 (2.8) | 77.2 (7.6) | 55.4 (5.6) |
Body mass index (kg/m2) a | 21.9 (3.8) | 21.7 (3.9) | 21.7 (3.8) | 22.0 (3.8) | 22.7 (4.0) |
<18.5 | 5576 (14.4) | 935 (16.3) | 926 (16.6) | 3581 (13.8) | 134 (9.7) |
18.5–24.9 | 26,341 (68.0) | 3886 (67.7) | 3788 (67.7) | 17,759 (68.3) | 908 (65.7) |
≥25.0 | 6805 (17.6) | 922 (16.0) | 879 (15.7) | 4665 (17.9) | 339 (24.6) |
Hypertension b | 11,034 (28.5) | 1230 (21.4) | 1382 (24.7) | 7800 (30.0) | 622 (45.0) |
Dyslipidemia c | 6267 (16.2) | 857 (14.9) | 829 (14.8) | 4238 (16.3) | 343 (24.8) |
Diabetes d | 2116 (5.5) | 377 (6.6) | 327 (5.9) | 1309 (5.0) | 103 (7.5) |
Hemoglobin A1c (%) a | 5.7 (0.5) | 5.7 (0.8) | 5.7 (0.6) | 5.7 (0.4) | 5.9 (0.6) |
Smoking status | |||||
Nonsmoker | 28,360 (73.2) | 3971 (69.2) | 3981 (71.2) | 19,321 (74.3) | 1087 (78.7) |
Ex-smoker | 2630 (6.8) | 453 (7.9) | 384 (6.9) | 1705 (6.6) | 88 (6.4) |
≤20 cigarettes/day | 6341 (16.4) | 1071 (18.6) | 985 (17.6) | 4116 (15.8) | 169 (12.2) |
>20 cigarettes/day | 411 (1.1) | 79 (1.4) | 65 (1.1) | 253 (1.0) | 14 (1.0) |
Unanswered | 980 (2.5) | 169 (2.9) | 178 (3.2) | 610 (2.3) | 23 (1.7) |
Alcohol consumption | |||||
Nondrinker | 20,024 (51.7) | 2833 (49.3) | 2737 (48.9) | 13,667 (52.6) | 787 (57.0) |
Occasional drinker | 12,591 (32.5) | 1988 (34.6) | 1979 (35.4) | 8226 (31.6) | 398 (28.8) |
Drinker <1 go/day e | 2317 (6.0) | 303 (5.3) | 298 (5.3) | 1621 (6.2) | 95 (6.9) |
Drinker ≥1 go/day e | 2810 (7.3) | 451 (7.9) | 400 (7.2) | 1881 (7.2) | 78 (5.6) |
Unanswered | 980 (2.5) | 168 (2.9) | 179 (3.2) | 610 (2.4) | 23 (1.7) |
Exercise, yes f | 4724 (12.2) | 530 (9.2) | 489 (8.7) | 3406 (13.1) | 299 (21.7) |
Anemia g | 7022 (18.1) | 1403 (24.4) | 1026 (18.3) | 4430 (17.0) | 163 (11.8) |
Job type | |||||
Professional job | 2731 (7.0) | 450 (7.8) | 466 (8.3) | 1744 (6.7) | 71 (5.1) |
Management | 688 (1.8) | 101 (1.8) | 101 (1.8) | 462 (1.8) | 24 (1.7) |
Office job | 14,755 (38.1) | 2216 (38.6) | 1967 (35.2) | 10,011 (38.5) | 561 (40.6) |
Sales | 2720 (7.0) | 579 (10.1) | 464 (8.3) | 1592 (6.1) | 85 (6.2) |
Service | 2579 (6.7) | 407 (7.1) | 433 (7.7) | 1669 (6.4) | 70 (5.1) |
Telecommunications | 293 (0.8) | 44 (0.8) | 34 (0.6) | 206 (0.8) | 9 (0.7) |
Manufacturing | 9503 (24.5) | 1156 (20.1) | 1375 (24.6) | 6624 (25.5) | 348 (25.2) |
Other | 4267 (11.0) | 577 (10.0) | 548 (9.8) | 2958 (11.4) | 184 (13.3) |
Unanswered | 1186 (3.1) | 213 (3.7) | 205 (3.7) | 739 (2.8) | 29 (2.1) |
eGFR (mL/min/1.73 m2) Groups | ||||
---|---|---|---|---|
≥90 | 60–89 | <60 | ||
High (≥97.4) | Low (90.0–97.3) | |||
Low frequency (1000 Hz) | ||||
Person-years | 63,645 | 65,077 | 338,372 | 15,717 |
No. of cases | 66 | 94 | 502 | 39 |
Crude HR (95% CI) | 0.72 (0.53–0.99) | Ref. | 1.02 (0.82–1.27) | 1.71 (1.18–2.49) |
Age-adjusted HR (95% CI) | 1.05 (0.77–1.44) | Ref. | 0.81 (0.65–1.01) | 0.85 (0.58–1.24) |
Multivariable-adjusted HR (95% CI) a | 1.01 (0.73–1.39) | Ref. | 0.84 (0.67–1.06) | 0.93 (0.63–1.36) |
Restricted to males without diabetes | 1.05 (0.75–1.48) | Ref. | 0.84 (0.66–1.07) | 0.86 (0.56–1.33) |
Restricted to nonsmokers | 0.70 (0.37–1.35) | Ref. | 0.65 (0.44–0.96) | 0.74 (0.41–1.35) |
Restricted to males aged <40 y.o. | 1.39 (0.63–3.08) | Ref. | 1.04 (0.50–2.19) | 3.27 (0.40–26.41) |
Restricted to office job | 0.69 (0.21–2.21) | Ref. | 0.64 (0.32–1.26) | 0.41 (0.11–1.52) |
Restricted to males with body mass index 18.5–24.9 kg/m2 | 1.10 (0.75–1.61) | Ref. | 0.85 (0.65–1.12) | 0.79 (0.47–1.36) |
Excluded males with low creatinine level b | 0.94 (0.64–1.39) | Ref. | 0.85 (0.68–1.06) | 0.93 (0.64–1.37) |
High frequency (4000 Hz) | ||||
Person-years | 62,814 | 64,047 | 332,901 | 15,383 |
No. of cases | 366 | 443 | 2379 | 161 |
Crude HR (95% CI) | 0.84 (0.73–0.97) | Ref. | 1.03 (0.93–1.14) | 1.51 (1.26–1.81) |
Age-adjusted HR (95% CI) | 1.22 (1.07–1.41) | Ref. | 0.82 (0.74–0.91) | 0.76 (0.63–0.91) |
Multivariable-adjusted HR (95% CI) a | 1.16 (1.01–1.34) | Ref. | 0.91 (0.82–1.01) | 0.95 (0.79–1.14) |
Restricted to males without diabetes | 1.15 (0.99–1.34) | Ref. | 0.90 (0.81–1.00) | 0.90 (0.73–1.10) |
Restricted to nonsmokers | 0.95 (0.69–1.31) | Ref. | 0.80 (0.65–0.98) | 0.86 (0.63–1.18) |
Restricted to males aged <40 y.o. | 0.89 (0.62–1.28) | Ref. | 0.74 (0.53–1.02) | 0.41 (0.06–2.97) |
Restricted to office job | 1.48 (0.78–2.81) | Ref. | 0.95 (0.59–1.51) | 0.94 (0.46–1.91) |
Restricted to males with body mass index 18.5–24.9 kg/m2 | 1.04 (0.88–1.23) | Ref. | 0.83 (0.74–0.94) | 0.88 (0.69–1.12) |
Excluded males with low creatinine level b | 1.14 (0.96–1.34) | Ref. | 0.91 (0.82–1.01) | 0.95 (0.79–1.15) |
eGFR (mL/min/1.73 m2) Group | ||||
---|---|---|---|---|
≥90 | 60–89 | <60 | ||
High (≥99.6) | Low (90.0–99.5) | |||
Low frequency (1000 Hz) | ||||
Person-years | 28,928 | 28,916 | 138,184 | 7270 |
No. of cases | 39 | 61 | 307 | 18 |
Crude HR (95% CI) | 0.63 (0.42–0.94) | Ref. | 1.04 (0.79–1.37) | 1.17 (0.69–1.98) |
Age-adjusted HR (95% CI) | 0.94 (0.63–1.41) | Ref. | 0.83 (0.63–1.10) | 0.63 (0.37–1.07) |
Multivariable-adjusted HR (95% CI) a | 0.90 (0.60–1.36) | Ref. | 0.85 (0.64–1.12) | 0.66 (0.39–1.12) |
Restricted to females without diabetes | 0.99 (0.63–1.54) | Ref. | 0.93 (0.68–1.25) | 0.82 (0.48–1.42) |
Restricted to nonsmokers | 0.98 (0.61–1.58) | Ref. | 0.88 (0.64–1.22) | 0.75 (0.42–1.33) |
Restricted to females aged <40 y.o. | 0.77 (0.33–1.79) | Ref. | 0.81 (0.38–1.72) | – (No event) |
Restricted to office job | 0.73 (0.32–1.69) | Ref. | 0.79 (0.46–1.34) | 0.37 (0.12–1.11) |
Restricted to females with body mass index 18.5–24.9 kg/m2 | 0.94 (0.56–1.58) | Ref. | 0.83 (0.58–1.17) | 0.75 (0.39–1.44) |
Excluded females with low creatinine level b | 0.88 (0.55–1.42) | Ref. | 0.85 (0.65–1.12) | 0.67 (0.39–1.14) |
High frequency (4000 Hz) | ||||
Person-years | 28,968 | 28,963 | 138,250 | 7247 |
No. of cases | 27 | 37 | 247 | 19 |
Crude HR (95% CI) | 0.73 (0.44–1.19) | Ref. | 1.39 (0.98–1.96) | 2.05 (1.18–3.55) |
Age-adjusted HR (95% CI) | 1.28 (0.77–2.12) | Ref. | 1.08 (0.77–1.53) | 0.98 (0.56–1.71) |
Multivariable-adjusted HR (95% CI) a | 1.23 (0.75–2.04) | Ref. | 1.13 (0.80–1.60) | 1.06 (0.61–1.85) |
Restricted to females without diabetes | 1.36 (0.80–2.31) | Ref. | 1.11 (0.77–1.61) | 0.73 (0.38–1.43) |
Restricted to nonsmokers | 1.31 (0.73–2.35) | Ref. | 1.10 (0.73–1.65) | 1.20 (0.65–2.22) |
Restricted to females aged <40 y.o. | 1.76 (0.44–7.09) | Ref. | 0.68 (0.16–2.78) | – (No event) |
Restricted to office job | 0.69 (0.23–2.05) | Ref. | 0.91 (0.47–1.78) | 0.14 (0.02–1.13) |
Restricted to females with body mass index 18.5–24.9 kg/m2 | 0.94 (0.50–1.78) | Ref. | 0.97 (0.65–1.46) | 0.61 (0.28–1.35) |
Excluded females with low creatinine level b | 1.02 (0.54–1.96) | Ref. | 1.13 (0.80–1.60) | 1.05 (0.60–1.83) |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Miyake, H.; Michikawa, T.; Nagahama, S.; Asakura, K.; Nishiwaki, Y. Estimated Glomerular Filtration Rate and Hearing Impairment in Japan: A Longitudinal Analysis Using Large-Scale Occupational Health Check-Up Data. Int. J. Environ. Res. Public Health 2022, 19, 12368. https://doi.org/10.3390/ijerph191912368
Miyake H, Michikawa T, Nagahama S, Asakura K, Nishiwaki Y. Estimated Glomerular Filtration Rate and Hearing Impairment in Japan: A Longitudinal Analysis Using Large-Scale Occupational Health Check-Up Data. International Journal of Environmental Research and Public Health. 2022; 19(19):12368. https://doi.org/10.3390/ijerph191912368
Chicago/Turabian StyleMiyake, Hiroshi, Takehiro Michikawa, Satsue Nagahama, Keiko Asakura, and Yuji Nishiwaki. 2022. "Estimated Glomerular Filtration Rate and Hearing Impairment in Japan: A Longitudinal Analysis Using Large-Scale Occupational Health Check-Up Data" International Journal of Environmental Research and Public Health 19, no. 19: 12368. https://doi.org/10.3390/ijerph191912368