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Article

Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle

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Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
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Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
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Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan
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Health & Wellness Products Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan
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Research and Development Headquarters, Lion Corporation, Odawara 256-0811, Japan
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TechnoSuruga Laboratory Co., Ltd., 388-1 Nagasaki, Shimizu-ku, Shizuoka 424-0065, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Francesco Campa and Maria Cristina Mele
Int. J. Environ. Res. Public Health 2022, 19(12), 7464; https://doi.org/10.3390/ijerph19127464
Received: 10 May 2022 / Revised: 14 June 2022 / Accepted: 16 June 2022 / Published: 17 June 2022
This study aimed to investigate the gut microbial genera associated with skeletal muscle mass, using a large-scale survey from the standpoint of preventing sarcopenia. A total of 848 participants were included in the analysis. The mean (SD) ages of men (n = 353) and women (n = 495) were 50.0 (12.9) years and 50.8 (12.8) years, respectively. Body composition was assessed using appendicular skeletal muscle mass/body weight (ASM/BW), ASM, and BW. Additionally, the relationship between gut microbial genera and body composition was analyzed. The means (SD) of ASM/BW were 34.9 (2.4) % in men and 29.4 (2.9) % in women. Blautia and Bifidobacterium were positively associated with ASM/BW only in men (Blautia: β = 0.0003, Bifidobacterium: β = 0.0001). However, Blautia was negatively associated with BW (β = −0.0017). Eisenbergiella was positively associated with ASM/BW (β = 0.0209) and negatively associated with BW (β = −0.0769) only in women. Our results indicate that Blautia, Bifidobacterium and Eisenbergiella, which are positively associated with ASM/BW, might help increase skeletal muscle mass. ASM/BW may clarify the relationship between gut microbiota and skeletal muscle mass without being affected by obesity or excess body fat mass. View Full-Text
Keywords: sarcopenia; gut microbiota; skeletal muscle mass; skeletal muscle mass index sarcopenia; gut microbiota; skeletal muscle mass; skeletal muscle mass index
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MDPI and ACS Style

Sugimura, Y.; Kanda, A.; Sawada, K.; Wai, K.M.; Tanabu, A.; Ozato, N.; Midorikawa, T.; Hisada, T.; Nakaji, S.; Ihara, K. Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle. Int. J. Environ. Res. Public Health 2022, 19, 7464. https://doi.org/10.3390/ijerph19127464

AMA Style

Sugimura Y, Kanda A, Sawada K, Wai KM, Tanabu A, Ozato N, Midorikawa T, Hisada T, Nakaji S, Ihara K. Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle. International Journal of Environmental Research and Public Health. 2022; 19(12):7464. https://doi.org/10.3390/ijerph19127464

Chicago/Turabian Style

Sugimura, Yoshikuni, Akira Kanda, Kaori Sawada, Kyi Mar Wai, Asano Tanabu, Naoki Ozato, Tatsuyuki Midorikawa, Takayoshi Hisada, Shigeyuki Nakaji, and Kazushige Ihara. 2022. "Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle" International Journal of Environmental Research and Public Health 19, no. 12: 7464. https://doi.org/10.3390/ijerph19127464

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