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Article

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

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Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
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Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
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Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia
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Social Sciences and Computing, University of Belgrade, 11000 Belgrade, Serbia
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Transfusion Medicine Department, Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia
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Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France
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Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
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Department of Microbiology, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
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Department of Microbiology with Parasitology and Immunology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
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Authors to whom correspondence should be addressed.
Academic Editors: Robert Colebunders and Jacob Souopgui
Int. J. Environ. Res. Public Health 2022, 19(1), 42; https://doi.org/10.3390/ijerph19010042
Received: 18 November 2021 / Revised: 15 December 2021 / Accepted: 16 December 2021 / Published: 21 December 2021
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)
Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals (n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals (p = 0.034), older age groups (p < 0.001), existence of hypertension (p = 0.008), and severe COVID-19 (p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity. View Full-Text
Keywords: SARS-CoV-2; COVID-19; convalescent plasma; Serbia; donors; therapy SARS-CoV-2; COVID-19; convalescent plasma; Serbia; donors; therapy
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MDPI and ACS Style

Grujić, J.; Bujandrić, N.; Budakov-Obradović, Z.; Dolinaj, V.; Bogdan, D.; Savić, N.; Cabezas-Cruz, A.; Mijatović, D.; Simin, V.; Anđelić, N.; Banović, P. Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors. Int. J. Environ. Res. Public Health 2022, 19, 42. https://doi.org/10.3390/ijerph19010042

AMA Style

Grujić J, Bujandrić N, Budakov-Obradović Z, Dolinaj V, Bogdan D, Savić N, Cabezas-Cruz A, Mijatović D, Simin V, Anđelić N, Banović P. Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors. International Journal of Environmental Research and Public Health. 2022; 19(1):42. https://doi.org/10.3390/ijerph19010042

Chicago/Turabian Style

Grujić, Jasmina, Nevenka Bujandrić, Zorana Budakov-Obradović, Vladimir Dolinaj, Damir Bogdan, Nebojša Savić, Alejandro Cabezas-Cruz, Dragana Mijatović, Verica Simin, Nikola Anđelić, and Pavle Banović. 2022. "Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors" International Journal of Environmental Research and Public Health 19, no. 1: 42. https://doi.org/10.3390/ijerph19010042

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