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Article

Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study

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National Defense Medical Center, Department of Psychiatry, Tri-Service General Hospital, Taipei 114, Taiwan
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Department of Psychiatry, Penghu Branch, Tri-Service General Hospital, Penghu 880, Taiwan
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Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
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Department of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan
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Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
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Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
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Department of Family Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan
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National Defense Medical Center, Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, Taipei 112, Taiwan
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National Defense Medical Center, Graduate Institute of Medical Sciences, Taipei 114, Taiwan
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Authors to whom correspondence should be addressed.
Academic Editors: Jitse P. van Dijk and Zuzana Dankulincova
Int. J. Environ. Res. Public Health 2021, 18(9), 4679; https://doi.org/10.3390/ijerph18094679
Received: 10 April 2021 / Revised: 23 April 2021 / Accepted: 25 April 2021 / Published: 28 April 2021
(This article belongs to the Collection Feature Papers in Children's Health)
Irritable bowel syndrome (IBS) is a functional bowel disorder that is highly comorbid with mental disorders. However, few studies have examined the risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder, major depressive disorder (MDD), and schizophrenia in the offspring of parents with IBS. We used nationally representative cross-sectional survey data to analyze cross-generational transmission patterns of both IBS and major mental disorders. Odds ratio (OR) was calculated by using logistic regression models with adjustment for potential confounding factors. Offspring of parents with IBS were more likely to develop IBS themselves (OR = 2.41, 95% confidence interval (CI), 2.09–2.78), ADHD (OR = 1.33, 95% CI, 1.08–1.62), and MDD (OR = 1.32, 95% CI, 1.04–1.68) than the controls. Data stratification by parental sex revealed that paternal IBS increased risk of ADHD (OR = 1.34, 95% CI, 1.01–1.77) in the offspring, while maternal IBS increased the risk of MDD (OR = 1.51, 95% CI, 1.11–2.06). This is the first study to reveal parental IBS is associated with IBS, ADHD, and MDD among offspring, suggesting the necessity for early implementation of prevention strategies for at-risk children. View Full-Text
Keywords: irritable bowel syndrome; neurodevelopmental disorders; mental disorders; genetic inheritance irritable bowel syndrome; neurodevelopmental disorders; mental disorders; genetic inheritance
MDPI and ACS Style

Yeh, T.-C.; Bai, Y.-M.; Tsai, S.-J.; Chen, T.-J.; Liang, C.-S.; Chen, M.-H. Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study. Int. J. Environ. Res. Public Health 2021, 18, 4679. https://doi.org/10.3390/ijerph18094679

AMA Style

Yeh T-C, Bai Y-M, Tsai S-J, Chen T-J, Liang C-S, Chen M-H. Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study. International Journal of Environmental Research and Public Health. 2021; 18(9):4679. https://doi.org/10.3390/ijerph18094679

Chicago/Turabian Style

Yeh, Ta-Chuan, Ya-Mei Bai, Shih-Jen Tsai, Tzeng-Ji Chen, Chih-Sung Liang, and Mu-Hong Chen. 2021. "Risks of Major Mental Disorders and Irritable Bowel Syndrome among the Offspring of Parents with Irritable Bowel Syndrome: A Nationwide Study" International Journal of Environmental Research and Public Health 18, no. 9: 4679. https://doi.org/10.3390/ijerph18094679

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